Butorphanol
Last updated: 08/04/2021
(Also known as: butorfanol)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Most commonly used as a narcotic for pain relief
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Horses, dogs, cats, ferrets, raccoons and some rodents
Isomeric
C₂₁H₂₉NO₂
C1CCC2(C3CC4=C(C2(C1)CCN3CC5CCC5)C=C(C=C4)O)O
C1CC[C@]2([C@H]3CC4=C([C@]2(C1)CCN3CC5CCC5)C=C(C=C4)O)O
IFKLAQQSCNILHL-QHAWAJNXSA-N
InChI=1S/C21H29NO2/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15/h6-7,13,15,19,23-24H,1-5,8-12,14H2/t19-,20+,21-/m1/s1
Yes
Analgesic, Medicinal drug
Benzylisoquinoline
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Synthetic
Intracellular inhibition of adenylate cyclase distrupting normal behaviour of membrane calcium and potassium channels.
[Kappa-type opioid receptor, agonist], [Delta-type opioid receptor, agonist], [Mu-type opioid receptor, agonist]
42408-82-2
255-808-8
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QN02AF01
Nervous system: Analgesics
No
No data
327.47
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17-cyclobutylmethyl-morphinan-3,14-diol
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Controlled substance
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White crystalline solid
Alvegesic vet
Alvetra u. Werfft A.G.
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Dolorex 10mg/mL Solution for Injection for horse, dog and cat
Intervet UK Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Torbutrol Tablets 10mg
Pfizer Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Morphasol 4 mg/ml solution for injection for dogs and cats
aniMedica GmbH
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Available in a variety of formulations including solutions for injection and tablets for oral administration
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 17
Rat
High
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 17
Rat
High
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Intraspinal TDLo = 0.035 mg kg⁻¹
Women
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Extensively metabolised by the liver and elimination occurs by urine and faecal excretion.
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
No data found
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
High doses may cause seizures, falling, salivation, constipation, and muscle twitching
No information available
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None - not a ppp
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butorphanol
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butorfanol
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Record last updated:
08/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242