Praziquantel
Last updated: 03/08/2022
(Also known as: biltricide; central praziquantel)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
An animal an anthelmintic effective against tapeworms and cestodes.
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Cats, Dogs
Isomeric. The commercial preparation is a mixture of equal parts of levo and dextro-isomers.
C₁₉H₂₄N₂O₂
C1CCC(CC1)C(=O)N2CC3C4=CC=CC=C4CCN3C(=O)C2
No data
FSVJFNAIGNNGKK-UHFFFAOYSA-N
InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
praziquantel
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Antiparasitic, Anthelmintic
Pyrazinaisoquinoline
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Synthetic
Though to cause parasitic paralysis leading to death. Disrupts Ca2+ homeostasis in adult worms.
[Schistosome Calcium (Ca 2+) Channel]
55268-74-1
259-559-6
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QP52 AA51
Antiparasitic products, insecticides & repellents: Anthelmintics
No
Allowable substance (Table 1: Ovine, Equidae)
312.41
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(RS)-2-(Cyclohexanecarbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one
2-Cyclohexylcarbonyl-1,2,3,6,11b-hexahydropyrazino[2,1a]isoquinoline-4-one
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Yellow to tan coloured solid
Big Cat Wormer Tablets
Bayer Plc
UK National authorisation (IC)
For non-food animal use and may be supplied without a prescription by a suitable qualified person (NFA-VPS)
Bob Martin Spot On Solution Dewormer
Bayer Plc
UK National authorisation (IC)
Authorised veterinary medicine for general sale (AVM - GSL)
Droncit Tablets 50 mg
Bayer Plc
UK National authorisation
Authorised veterinary medicine for general sale (AVM - GSL)
Dolpac Tablets for Large Dogs
Vetoquinol Uk Ltd
EU Mutually recognised procedure
For non-food animal use and may be supplied without a prescription by a suitable qualified person (NFA-VPS)
Available in a wide variety of formulations including tablets, solutions for injection, oral pastes, oral suspensions and spot-on solutions
400
Moderate
97000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Ethanol
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567000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Chloroform
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136
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544
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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255
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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2.63 X 1002
Calculated
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2.42
Low
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1.22
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 2840
Rat
Low
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> 12.2
Clarias gariepinus
Moderate
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30.07
R4 R = Peer reviewed scientific publications 4 = Verified data
Daphnia magna
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 2840
Rat
Low
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Intraperitoneal LD₅₀ = 586 mg kg⁻¹
Rat
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Intramuscular LD₅₀ > 2000 mg kg⁻¹
Rat
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Excreted mainly via the urine
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May cause abdominal pain or cramps Possible liver toxicant
No information available
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Not listed (Not listed)
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praziquantel
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Record last updated:
03/08/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242