Bromhexine hydrochloride
Last updated: 24/02/2022
(Also known as: bisolvon hydrochloride; bromohexine hydrochloride)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Used in the control of respiratory disease involving production of excessive tenacious mucus
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Cats, Dogs, Cattle, Pigs, Sheep, Pigeons
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C₁₄H₂₁Br₂ClN₂
CN(CC1=CC(=CC(=C1N)Br)Br)C2CCCCC2.Cl
No data
UCDKONUHZNTQPY-UHFFFAOYSA-N
InChI=1S/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
bromhexine hydrochloride
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Medicinal drug, Antibiotic, Expectorant
Unclassified substance
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Synthetic
Acts on the mucus at the formative stages in the glands, within the mucus-secreting cells.
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611-75-6
210-280-8
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QR05CB02
Respiratory system: Cough and cold preparations
No
No data
412.59
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2-amino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemethamine hydrochloride
N-cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)ammonium
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White crystalline powder
Bisolvon 10 mg/g oral powder
Boehringer Ingelheim Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Bisolvon 3 mg/ml Solution for Injection
Boehringer Ingelheim Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as oral powders or solutions for injection
4.0
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Low
10.0
Q2 Q = Miscellaneous internet resources 2 = Unverified data of unknown source
Ethanol
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0.2
Chloroform
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235
Decomposes
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Decomposes on melting
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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235
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 6000
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Rat
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 6000
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Rat
Low
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Subcutaneous LD₅₀ > 14000 mg kg⁻¹
Rat
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Intraperitoneal LD₅₀ = 1680 mg kg⁻¹
Rat
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Rapidly absorbed from the gastrointestinal tract and metabolises in the liver, excreted as metabolites in the urine
Q4 Q = Miscellaneous internet resources 4 = Verified data
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
No data found
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
Prolonged exposure to the substance can produce target organs damage May cause gastrointestinal disturbances
No information available
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None - not a ppp
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bromhexine hydrochloride
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bromessina
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Record last updated:
24/02/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242