Buprenorphine
Last updated: 30/08/2023
(Also known as: probuphenine; RX-6029-M)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Used as an analgesic agent for a variety of animals
-
-
Horses, Hedgehogs, Sheep, Dogs, Cats
Isomeric
C₂₉H₄₁NO₄
CC(C)(C)C(C)(C1CC23CCC1(C4C25CCN(C3CC6=C5C(=C(C=C6)O)O4)CC7CC7)OC)O
C[C@]([C@H]1C[C@@]23CC[C@@]1([C@H]4[C@@]25CCN([C@@H]3CC6=C5C(=C(C=C6)O)O4)CC7CC7)OC)(C(C)(C)C)O
RMRJXGBAOAMLHD-IHFGGWKQSA-N
InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29-/m1/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
buprenorphine
-
Analgesic, Medicinal drug
Opioid
-
-
Synthetic
Acts as an epsilon-opioid antagonist
[Mu-type opioid receptor, partial agonist], [Kappa-type opioid receptor, antagonist], [Delta-type opioid receptor, antagonist]
52485-79-7
257-950-6
-
-
644073
QN02AE01
Nervous system: Analgesics
Yes - Group 3
No data
467.65
-
(2S)-2-[(-)-(5R,6R,7R,14S)-9α-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylbutan-2-ol
17-(cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanol; Buprenex
-
-
White crystalline powder
Buprecare 0.3 mg/ml Solution for Injection for Dogs and Cats
Animalcare Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Vetergesic, 0.3mg/ml solution for injection for Dog and Cats
Reckitt Benckiser Healthcare UK Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Buprenodale Vet 0.3mg/mL solution for injection for dogs and cats
Decra Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Budale 0.3mg/mL solution for injection for dogs and cats
Decra Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as solution for injection
0.636
Low
-
-
-
209
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
-
-
-
-
-
-
-
-
-
9.55 X 1004
Calculated
-
4.98
High
-
-
-
-
-
-
-
-
-
8.31
at 25°C
-
-
1.23 X 10-08
Low volatility
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Soil adsorption and mobility
-
-
-
-
-
-
-
-
Known soil and groundwater metabolites
None
norbuprenorphine Note: Pharmacologically active
-
Human (Liver)
-
Cytochrome P450 3A5 Cytochrome P450 3A4 Cytochrome P450 2C9 Cytochrome P450 2C8
hydroxybuprenorphine
-
Human (Liver)
-
Cytochrome P450 3A5 Cytochrome P450 3A4 Cytochrome P450 3A7
buprenorphine glucuronide
-
Human (Liver)
-
UDP-glucuronosyltransferase 1-9
Terrestrial ecotoxicology
243
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
HUMAN HEALTH AND PROTECTION
High (class III)
-
-
243
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Moderate
-
-
-
-
-
-
Intraperitoneal LD₅₀ = 90 mg kg⁻¹
Mouse
-
Intravenous LD₅₀ = 197 mg kg⁻¹
Rat
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Liver metabolism, excreted ~70 in bile and ~30% in urine
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
-
Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
XNo, known not to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
No data found
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
May cuase respiratory depression, decreased blood pressure and heart rate
No information available
-
Not listed (Not listed)
-
-
-
buprenorphine
-
-
-
-
buprenorfina
-
-
-
-
-
-
Record last updated:
30/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242