Xylazine hydrochloride
Last updated: 04/08/2022
(Also known as: xylene HCl; BAY 1470 hydrochloride; xylazine chloride )
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
Drug used to produce sedation and short periods of analgesia in a range of animals
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1962, first synthesised
Horses, Cattle, Elephants, Deer, Cats, Dogs, Sheep, Goats, Hedgehogs, Other farm livestock and zoo animals
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C₁₂H₁₇ClN₂S
c1(C)c(NC=2SCCCN2)c(ccc1)C.Cl
No data
QYEFBJRXKKSABU-UHFFFAOYSA-N
InChI=1S/C12H16N2S.ClH/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);1H
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
xylazine hydrochloride monohydrate
monohydrate
Sedative, Anesthestic, Analgesis, Muscle relaxant, Medicinal drug
Clonidine analoque
>99%
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Synthetic
Inhibits the effects of postganglionic nerve stimulation.
[alpha-2-adrenergic, agonist]
23076-35-9
245-417-0
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QN05CM92
Nervous system: Psycholeptics
No
Allowed substance (Table 1: Bovine, Equidae)
256.79
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2-(2,6-xylidino)-5,6-dihydro-4H-1,3-thiazine hydrochloride
N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazine-2-amine hydrochloride
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White crystalline solid
Rompun 2% w/v solution for injection
Bayer plc
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Rompun dry substance 500mg powder and solvent for injection
Bayer plc
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Sedaxylan 20 mg/ml solution for injection
Eurovet Animal Health BV
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Xylapan 20mg solution for injection
Vetoquinol UK Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied in solution for injection or as a powder to be prepared as a solution
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164
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
1-amino-2,6-dimethylbenzene
2,6-xylidine
Cattle (Urine)
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2-(4'-hydroxy-2',6'-di-methylphenylamino)-5,6-dihydro-4H-1,3-thiazine
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Horses; Rats (liver)
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2-(3'-hydroxy-2',6'-dimethylphenylamino)-5,6-dihydro-4H-1,3-thiazine
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Horses; Rats (liver)
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N-(2,6-dimethylphenyl)thiourea
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Horses; Rats (liver)
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2-(2',6'-dimethylphenylamino)-4-oxo-5,6-dihydro-1,3-thiazine
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Horses; Rats (liver)
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Terrestrial ecotoxicology
> 109
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Mouse
Moderate
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> 18.0
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Daphnia magna
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 109
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Mouse
Moderate
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Subcutaneous TDLo = 0.029 mL kg⁻¹
Mouse
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Intramuscular TDLo = 109 mg kg⁻¹
Mouse
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Extensive metabolism occurs with <1% unchanged being eliminated via urine in the first two hours after administration
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Possible liver toxicant Adverse effects of xylazine in animals include muscle tremors, seizures and slowed heart rate May cause vomiting
No information available
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Not listed (Not listed)
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xylazine hydrochloride
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Record last updated:
04/08/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242