Dinoprost
Last updated: 08/04/2021
(Also known as: prostaglandin F2alpha; dinoprost trometamol ; PGF2 alpha THAM; prostaglandin F2 alpha tromethamine ; amoglandin)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Used for inducing abortion and at low-doses for medically indicated induction of labor at full term
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Horses, Cattle, Pigs
No data
C₂₀H₃₄O₅
CCCCCC(C=CC1C(CC(C1CC=CCCCC(=O)O)O)O)O
CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O)O
PXGPLTODNUVGFL-YNNPMVKQSA-N
InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
Yes
Abortifacient agent, Reproduction control, Medicinal drug
Unclassified substance
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Natural
Stimulates myometrial contractions in the gravid uterus that are similar to the contractions that occur in the term uterus during labor
[Prostaglandin F2-alpha receptor, agonist], [Prostacyclin receptor, antagonist]
551-11-1
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QG02AD
Genito Urinary system & sex hormones: Other gynecologicals
No
Allowed substance (Table 1: All mammalian food producing species)
354.48
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(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)- 3-hydroxyoct-1-enyl]cyclopentylhept-5-enoic acid
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White to off-white, very hygroscopic, crystalline powder
Cycloprost 5mg/ml Solution for injection
Norbrook labs
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Lutalyse 5 mg/ml Solution for Injection
Pfizer Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Enzaprost 5 mg/ml Solution for injection for cattle and pigs
Ceva Animal Health Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Ceveprost 5 mg/ml Solution for injection for cattle and pigs
Ceva Animal Health Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as solution for injection
2.58
Low
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30
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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2.45 X 1004
Calculated
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4.39
High
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5.01 X 10-09
Low volatility
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 1170
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Moderate
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HUMAN HEALTH AND PROTECTION
Low (class I)
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> 1170
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Moderate
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Subcutaneous LD₅₀ = 95 mg kg⁻¹
Rat
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Intramuscular LD₅₀ = 106 mg kg⁻¹
Rat
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Mostly excreted in the urine, only around 5% lost via the faeces
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
Large doses may cause nausea, vomiting, and diarrhoea
No information available
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Not listed (Not listed)
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dinoprost
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dinoprosta
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Record last updated:
08/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242