Isoflurane
Last updated: 09/06/2022
(Also known as: forane)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A substance used for inhalational anesthesia
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Elephants, Bears, Cats, Dogs, Horses, Fowls, Mammals, Reptiles, Caged birds, Rodents
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C₃H₂ClF₅O
C(C(F)(F)F)(OC(F)F)Cl
No data
PIWKPBJCKXDKJR-UHFFFAOYSA-N
InChI=1S/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
isoflurane
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Anesthesetic
Halogenated ether
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Synthetic
Involves interactions with multiple receptor sites to interfere with synaptic transmission.
[Gamma-aminobutyric-acid (GABA) receptor subunit alpha-1, agonist], [Calcium-transporting ATPase type 2C member 1, antagonist], [Glycine receptor subunit alpha-1, agonist], [Glutamate receptor 1, antagonist], [Potassium voltage-gated channel subfamily A member 1, agonist], [ATP synthase delta chain, mitochondrial], [Calmodulin]
26675-46-7
247-897-7
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QN01AB06
Nervous system: Anaesthetics
No
Allowed substance (Table 1: Equidae)
184.49
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2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethane
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Clear, colourless liquid
Isocare 100% w.v inhalation vapour, liquid
Piramal Health Care UK Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Isofane 100% w.v inhalation vapour, liquid
Piramal Health Care UK Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Isoflow 100% w/w inhalation vapour, liquid
Abbott Laboratories Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Vetflurane 100% inhalation vapour, liquid
Virbac Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as a liquid from which vapours re inhaled
4470
High
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Not applicable
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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48.5
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1.15 X 1002
Calculated
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2.06
Low
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1.45
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
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31.7 X 1006
Highly volatile
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1.2990-1.3005
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
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HUMAN HEALTH AND PROTECTION
High (class III)
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15.3
Rat 3 hr
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Intraperitoneal LD₅₀ = 4.28 mL kg⁻¹
Rat
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Mainly eliminated via the lungs
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
Strong respiratory depressant Muscle relaxant May cause hypotension
Not expected to auto-ignite; Not highly flammable
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Not listed (Not listed)
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isoflurane
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isoflurano
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Record last updated:
09/06/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242