Griseofulvin
Last updated: 11/09/2023
(Also known as: grisovin; delmofulvina; grisefuline; (+)-griseofulvin)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
Natural substance to treat fungal infections of the skin, such as ringworm, and nails
Considered obsolete but may be available in some countries
1939, first reported
Horses
Griseofulvin is a chiral molecule. Substance is racemic.
C₁₇H₁₇ClO₆
CC1CC(=O)C=C(C12C(=O)C3=C(O2)C(=C(C=C3OC)OC)Cl)OC
C[C@@H]1CC(=O)C=C([C@]12C(=O)C3=C(O2)C(=C(C=C3OC)OC)Cl)OC
DDUHZTYCFQRHIY-RBHXEPJQSA-N
InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
griseofulvin
Unstated isomer
Fungicide, Antifungal, Antibiotic
Benzofuran fungicide
97%
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Natural
Acts by binding to keratin in keratin precursor cells making them resistant to fungal infections.
[Tubulin beta chain, antagonist], [Tubulin alpha chain, antagonist], [Keratin, type I cytoskeletal 12]
126-07-8
204-767-4
308
471400
441140
No data found
QD01BA01
Dermatologicals: Antifungals for dermatological use
No
No data
352.77
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(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro [1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
7-chloro-4,6-dimethoxycoumaran-3-one-2-spiro-1'-(2'-methoxy-6'-methylcyclohex-2'-en-4'-one)
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White to pale cream-coloured, odourless crystalline powder
Grisol V Granules 7.5%
Vetoquinol UK Limited
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Grisol V Powder 7.5% w/w oral powder
Vetoquinol UK Limited
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Norofulvin 33.3% w/w Equine Oral Paste
Norbrook Labs
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Norofulvin 7.5% w/w Granules for Top Dressing Use
Norbrook Labs
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Was available in a variety of formulations including oral powders, pastes and granules for top dressing use
8.64
Low
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218
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
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570
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
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210
sublimes
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228
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
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2.29 X 1002
Calculated
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2.36
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Low
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1.43
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
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1.28 X 10-03
Low volatility
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Max 286nm and 325nm
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1.5403
at 25°C
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
6-dimethylgriseofulvin
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Mammals (Urine)
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Terrestrial ecotoxicology
> 10000
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Low
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> 1000
R4 R = Peer reviewed scientific publications 4 = Verified data
Daphnia magna
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 10000
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Low
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Intraperitoneal LD₅₀ > 5000 mg kg⁻¹
Rat
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Subcutaneous LD₅₀ > 12000 mg kg⁻¹
Mouse
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Excreted mainly in the urine and faeces. Deposited in varying concentrations in the keratin layer of the skin, hair, and nails
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Carcinogen
Endocrine disruptor
?Possibly, status not identified
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E1 E = Unspecified genotoxicity type (miscellaneous data source) 1 = Positive
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
✓Yes, known to cause a problem
 
IARC Group 2B carcinogen; CLP data - suspected carcinogen May cause nausea, diarrhoea, hives, hives and fatigue Possible blood and liver toxicant
When heated to decomposition it emits toxic fumes of halogen gases
Health: H317, H351, H360 Environment: H411
Not classified: Obsolete (Not classified: Obsolete)
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griseofulvin
griseofulvine
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griseofulvina
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Record last updated:
11/09/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242