Clomipramine hydrochloride
Last updated: 30/08/2023
(Also known as: clomipramine HCl ; monochlorimipramine HCl; 3-chloroimipramine hydrochloride)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Widely used for the treatment of disturbed behaviour of dogs, cats, and horses
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circa 1960s, discovered
Cats, Dogs, Horses
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C₁₉H₂₄Cl₂N₂
CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl.Cl
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WIMWMKZEIBHDTH-UHFFFAOYSA-N
InChI=1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
Yes
Antidepressant, Medicinal drug
Unclassified substance
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Synthetic
Largely unclear but though to inhibit norepinephrine and serotonin uptake into central nerve terminals
[Sodium-dependent serotonin transporter, antagonist], [5-hydroxytryptamine 2A receptor, antagonist], [5-hydroxytryptamine 2B receptor, antagonist], [5-hydroxytryptamine 2C receptor, antagonist], [Sodium-dependent noradrenaline transporter, antagonist], [Glutathione S-transferase P, antagonist]
17321-77-6
241-344-3
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68539
QN06AA04
Nervous system: Psychoanaleptics
No
No data
351.32
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3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine monohydrochloride
5H-dibenz(b,f)azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-, monohydrochloride
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Off-white coloured solid
Clomicalm 5mg tablets for dogs
Novartis Animal Health UK Ltd
EU Centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Clomicalm 20mg tablets for dogs
Novartis Animal Health UK Ltd
EU Centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Clomicalm 80mg tablets for dogs
Novartis Animal Health UK Ltd
EU Centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied in tablet form for oral administration
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
desmethylclomipramine
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Humans (Liver)
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Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 2C19
8-hydroxyclomipramine
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clomipramine N-oxide
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2-hydroxyclomipramine
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Terrestrial ecotoxicology
470
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Mouse
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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470
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Mouse
Moderate
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Subcutaneous LD₅₀ = 1750 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 26 mg kg⁻¹
Rat
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Around 50-60% of administered dose is elminated in the urine and about 20-30% in faeces. Also found in human milk
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
✓Yes, known to cause a problem
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
✓Yes, known to cause a problem
 
May cause fatigue, dizziness, lightheadedness, headaches, confusion, agitation and various other side effects
No information available
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Not listed (Not listed)
Not regulated
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clomipramine hydrochloride
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clomipramina
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Record last updated:
30/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242