Cloprostenol sodium
Last updated: 30/08/2023
(Also known as: estrophane; oestrophane)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Used as a luteolytic agent to shorten the cycle or induce cows to come into heat
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Cattle, Pigs, Sheep, Horses
Isomeric
C₂₂H₂₈ClO₆Na
C1C(C(C(C1O)C=CC(COC2=CC(=CC=C2)Cl)O)CC=CCCCC(=O)[O-])O.[Na+]
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IFEJLMHZNQJGQU-UDEWSXLWSA-M
InChI=1S/C22H29ClO6.Na/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28;/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28);/q;+1/p-1
Yes
Fertility drug, Medicinal drug
Prostaglandin
~98%
15S-cloprostenol ~1%; 5,6-trans-cloprostenol ~2%
Synthetic
Induces in a sharp fall in progesterone levels
[Prostaglandin F2-alpha receptor, agonist]
55028-72-3
255-028-8
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44134632
QG02AD90
Genito urinary system & sex hormones: Prostaglandins
No
Allowed substance (Table 1: Bovine, Porcine, Caprine, Equidae)
446.92
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7-[2-[4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate, sodium salt
(+)-16-m-chlorophenoxy tetranor Prostaglandin F2a (sodium salt), superphan, D-cloprostenol
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White amorphous, hygroscopic powder
Cyclix solution for injection 250 ug/ml
Virbac S.A
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Dalmazin 75 ug/ml solution for injection for cows and sows
FATRO S.p.A.
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Juramate 250 µg/ml Solution for Injection
Jurox (UK) plc
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Planate 0.0875 mg/ml Solution for injection
Schering Plough Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as solution for injection
10
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Low
50000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Ethanol
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60000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
DMSO
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130000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Dimethylformamide
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69
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
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Max: 220nm, 275nm, 282nm
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
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E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
High
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HUMAN HEALTH AND PROTECTION
High (class III)
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E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
High
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May be absorbed through the skin
Eliminated in approximately equal amounts via the kidney and in bile. Excretion in urine is partly as unchanged parent and partly as metabolites.
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Possible sensitiser May cause vomiting and nausea
No information available
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Not listed (Not listed)
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cloprostenol sodium
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Record last updated:
30/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242