Atropine sulphate
Last updated: 30/08/2023
(Also known as: atropine sulfate; atropa belladonna)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
Used as aa parasympatholytic and as an partial antidote to organophosphorus poisoning.
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Horses, Dogs, Cats
Isomeric
C₁₇H₂₃NO₃
CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
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RKUNBYITZUJHSG-UHFFFAOYSA-N
InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
D,L-Atropine
Parent
Analgesic, Medicinal drug
Plant alkaloid
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Natural
An antagonist for the muscarinic acetylcholine receptor
[Muscarinic acetylcholine receptor M1, antagonist], [Muscarinic acetylcholine receptor M2, antagonist], [Muscarinic acetylcholine receptor M3, antagonist], [Muscarinic acetylcholine receptor M4, antagonist], [Muscarinic acetylcholine receptor M5, antagonist]
55-48-1
200-235-0
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3661
QA03BA01
Alimentary tract & metabolism: Drugs for functional gastrointestinal disorders
No
Allowed substance (Table 1: All food producing species)
289.4
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[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate
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White granular powder
Atrocare 600 ug/ml Solution for Injection
Animalcare Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as solution for injection
3940
High
2380
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Chloroform
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330
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Ether
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400000
l3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Glycerol
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190
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
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Decomposes before boiling
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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8.13 X 1001
Calculated
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1.91
Low
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2.59 X 10-03
Low volatility
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
tropic acid
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Mammals
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tropine
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Mammals
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Terrestrial ecotoxicology
75
Rat
High
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258
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Daphnia magna 24 hour
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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75
Rat
High
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Subcutaneous LD₅₀ = 540 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 37 mg kg⁻¹
Rat
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Approx. 50% hydrolysed and 50% excreted unchanged in urine
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
✓Yes, known to cause a problem
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Highly toxic to lungs, the nervous system and mucous membranes May cause nausea or vomiting May cause confusion and nervousness
IMDG Transport Hazard Class 6.1
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Not listed (Not listed)
UN1544
Packaging Group II (moderate danger)
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atropine sulphate
sulfate d'atropine
Atropinsulfat
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atropiny siarczan
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Record last updated:
30/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242