The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Systemic. Metronidazole is reduced as it enters the target cell where it interacts with bacterial or protozoal DNA causing a loss of helical structure and strand breakage in the DNA leading to eventual death of the cell
Eliminated with some hepatic metabolism mainly in the faeces but some also lost with urine
V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source
-
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
?Possibly, status not identified
A0 A = Chromosome aberration (EFSA database) 0 = No data
;
B0 B = DNA damage/repair (EFSA database) 0 = No data
;
C0 C = Gene mutation (EFSA database) 0 = No data
;
D0 D = Genome mutation (EFSA database) 0 = No data
;
E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
General human health issues
May cause headaches, nausea and diarrhoea Associated with the development of leukopenia, neutropenia and increased risk of peripheral neuropathy Published studies suggest substance is potentially carcinogenic; WHO & IARC - possible carcinogen; CLP data - inadequate epidemiological evidence so substance is not considered as a risk factor for cancer in humans; US NTP - suspected carcinogen; OSHA - Anticipated human carcinogen
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242