Sulphadimidine
Last updated: 26/04/2021
(Also known as: sulfadimidine; sulfamethazine; sulphamethazine; SDI; sulfadimerazine)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Widely used in veterinary medicine to treat various problems including bovine respiratory disease, calf diphtheria, bacterial pneumonia and procine colibacillosis as wel as coccidiosis, fowl cholera and pullorum disease.
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Possible groundwater contaminant
Pigs, Fowl, Cattle, Sheep
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C₁₂H₁₄N₄O₂S
CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)N)C
No data
ASWVTGNCAZCNNR-UHFFFAOYSA-N
InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
sulphadimidine
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Antibacterial, Anti-infective, Antibiotic, Antimicrobial, Medicinal drug
Sulfonamide
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Synthetic
A competitive inhibitor of dihydropteroate synthase
[Dihydropteroate synthetase, antagonist]
57-68-1
200-346-4
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QP51AG01; QJ01EQ
Antiparasitic products, insecticides & repellents: Antiprotozoals; Antiinfectants for systemic use: Antibacterials for systemic use
No
Allowed substance (Table 1: All food producing species)
278.33
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4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
4,6-dimethyl-2-sulfanilamidopyrimidine
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White crystalline powder
Intradine 30.89% w/v Solution for Injection
Norbrook Labs
UK National Authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Sulpha No.2 Powder for Oral Solution
Chanelle Pharmaceuticals Manufacturing Ltd
No UK authorisation for use with animals, Authorised for use in Ireland
Not applicable
Usually supplied as solutions for injection or as oral solutions
1500
R4 R = Peer reviewed scientific publications 4 = Verified data
High
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176
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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Decomposes before boiling
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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7.76 X 1000
Calculated
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0.89
R4 R = Peer reviewed scientific publications 4 = Verified data
Low
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7.59
R4 R = Peer reviewed scientific publications 4 = Verified data
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4.85 X 10-06
R4 R = Peer reviewed scientific publications 4 = Verified data
Low volatility
3.09 X 10-11
R4 R = Peer reviewed scientific publications 4 = Verified data
Non-volatile
Acidic: max at 241nm and 297nm Neutral: max at 241nm Basic: max at 243nm and 257nm
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15044
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18.6
R4 R = Peer reviewed scientific publications 4 = Verified data
Non-persistent
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Hydolysis not expected
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Soil adsorption and mobility
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Moderately mobile
127
General literature Koc values range 46 (silt loam) - 208 (sandly loam) mL g⁻¹
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2.41
Calculated
Transition state
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Known soil and groundwater metabolites
None
N4-acetylated sulfonamide
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Human (Liver)
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Terrestrial ecotoxicology
> 2000
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Mouse
Low
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> 131
R4 R = Peer reviewed scientific publications 4 = Verified data
Daphnia magna
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 2000
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Mouse
Low
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Subcutaneous LD₅₀ > 2000 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 2450 mg kg⁻¹
Rabbit
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Partly metabolibised and eliminated predominately in urine with lesser amounts in faeces, bile and milk.
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Carcinogen
Endocrine disruptor
?Possibly, status not identified
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
?Possibly, status not identified
✓Yes, known to cause a problem
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Harmful if inhaled may cause gastric irritation and vomiting Possible liver and kidney toxicant
Light sensitive
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None - not a ppp
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sulphadimidine
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sulfametazina
sulfadimidina
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sulfametazina
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Record last updated:
26/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242