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Sulphadimidine
Last updated: 26/04/2021
(Also known as: sulfadimidine; sulfamethazine; sulphamethazine; SDI; sulfadimerazine)
Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate Ecotoxicity Human health
Environmental fate
Moderate alert:
GUS: Transition state; Drainflow: Moderately mobile
Warning:
Significant data are missing
Ecotoxicity
Low alert:
Daphnia acute ecotoxicity: Low
Warning:
Significant data are missing
Human health
High alert:
Reproduction/development effects; Neurotoxicant
GENERAL INFORMATION
Description
Widely used in veterinary medicine to treat various problems including bovine respiratory disease, calf diphtheria, bacterial pneumonia and procine colibacillosis as wel as coccidiosis, fowl cholera and pullorum disease.
Availability status
-
Introduction & key dates
Possible groundwater contaminant
Examples of species treated
Pigs, Fowl, Cattle, Sheep
Chemical structure
Isomerism
-
Chemical formula
C₁₂H₁₄N₄O₂S
Canonical SMILES
CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)N)C
Isomeric SMILES
No data
International Chemical Identifier key (InChIKey)
ASWVTGNCAZCNNR-UHFFFAOYSA-N
International Chemical Identifier (InChI)
InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)
2D structure diagram/image available?
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name Relationship Link
sulphadimidine -
General status
Veterinary substance type
Antibacterial, Anti-infective, Antibiotic, Antimicrobial, Medicinal drug
Substance groups
Sulfonamide
Minimum active substance purity
-
Known relevant impurities
-
Substance origin
Synthetic
Mode of action
A competitive inhibitor of dihydropteroate synthase
Molecular targets
[Dihydropteroate synthetase, antagonist]
CAS RN
57-68-1
EC number
200-346-4
CIPAC number
-
US EPA chemical code
-
PubChem CID
-
ATCvet Code
QP51AG01; QJ01EQ
Therapeutic Class
Antiparasitic products, insecticides & repellents: Antiprotozoals; Antiinfectants for systemic use: Antibacterials for systemic use
Controlled Drug?
No
Regulation 37/2010 MRL Classification
Allowed substance (Table 1: All food producing species)
Molecular mass
278.33
PIN (Preferred Identification Name)
-
IUPAC name
4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
CAS name
4,6-dimethyl-2-sulfanilamidopyrimidine
Other status information
-
Relevant Environmental Water Quality Standards
-
Physical state
White crystalline powder
Formulations
Property
Product
Manufacturer
Authorisation Route
UK Legal Class
Example products using this active
Intradine 30.89% w/v Solution for Injection Norbrook Labs UK National Authorisation Prescription only medicine to be authorised by a veterinarian (POM-V)
Sulpha No.2 Powder for Oral Solution Chanelle Pharmaceuticals Manufacturing Ltd No UK authorisation for use with animals, Authorised for use in Ireland Not applicable
Formulation and application details
Usually supplied as solutions for injection or as oral solutions
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
1500
R4 R = Peer reviewed scientific publications
4 = Verified data
 High
Solubility - In organic solvents at 20 °C (mg l⁻¹)
- - -
Melting point (°C)
176
Q3 Q = Miscellaneous internet resources
3 = Unverified data of known source
 -
Boiling point (°C)
Decomposes before boiling
Q3 Q = Miscellaneous internet resources
3 = Unverified data of known source
 -
Degradation point (°C)
- - -
Flashpoint (°C)
- - -
Octanol-water partition coefficient at pH 7, 20 °C
P
7.76 X 1000 Calculated -
Log P
0.89
R4 R = Peer reviewed scientific publications
4 = Verified data
 Low
Fat solubility of residues
Solubility
- - -
Data type
- - -
Density (g ml⁻¹)
- - -
Dissociation constant pKa) at 25 °C
7.59
R4 R = Peer reviewed scientific publications
4 = Verified data
 -
-
Vapour pressure at 20 °C (mPa)
4.85 X 10-06
R4 R = Peer reviewed scientific publications
4 = Verified data
 Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
3.09 X 10-11
R4 R = Peer reviewed scientific publications
4 = Verified data
 Non-volatile
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
Acidic: max at 241nm and 297nm
Neutral: max at 241nm
Basic: max at 243nm and 257nm
CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here )
3 = Unverified data of known source
 -
Surface tension (mN m⁻¹)
- - -
Refractive Index
15044
CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here )
3 = Unverified data of known source
 -
Degradation
Property
Value
Source; quality score; and other information
Interpretation
Soil degradation (days) (aerobic)
DT₅₀ (typical)
18.6
R4 R = Peer reviewed scientific publications
4 = Verified data
 Non-persistent
DT₅₀ (lab at 20 °C)
- - -
DT₅₀ (field)
- - -
DT₉₀ (lab at 20 °C)
- - -
DT₉₀ (field)
- - -
Note
-
Manure DT₅₀ (days)
- - -
Aqueous photolysis DT₅₀ (days) at pH 7
Value
- - -
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
-
CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here )
3 = Unverified data of known source
 -
Note
Hydolysis not expected
Water-sediment DT₅₀ (days)
- - -
Water phase only DT₅₀ (days)
- - -
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd
-
CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here )
3 = Unverified data of known source
 Moderately mobile
Koc
127
Notes and range
General literature Koc values range 46 (silt loam) - 208 (sandly loam) mL g⁻¹
Freundlich
Kf
- - -
Kfoc
-
1/n
-
Notes and range
-
pH sensitivity
-
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
2.41 Calculated Transition state
Bio-concentration factor
BCF (l kg⁻¹)
- - -
CT₅₀ (days)
- -
Known soil and groundwater metabolites

None

Other known metabolites
Metabolite name and reference
Aliases
Formation medium / Rate
Estimated maximum occurrence fraction
Metabolising enzymes
N4-acetylated sulfonamide - Human (Liver) - -
ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 2000
Q3 Q = Miscellaneous internet resources
3 = Unverified data of known source
Mouse		 Low
Mammals - Short term dietary NOEL
(mg kg⁻¹)
- - -
(ppm diet)
- -
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
- - -
Birds - Acute LD₅₀ (mg kg⁻¹)
- - -
Birds - Short term dietary (LC₅₀/LD₅₀)
- - -
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
- - -
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
- - -
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
- - -
Soil micro-organisms
- - -
Collembola
Acute LC₅₀ (mg kg⁻¹)
- - -
Chronic NOEC (mg kg⁻¹)
- - -
Non-target plants
- - -
- - -
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Chronic
- - -
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Other pollinators (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Other pollinators (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Beneficial insects (Ladybirds)
- - -
Beneficial insects (Lacewings)
- - -
Beneficial insects (Parasitic wasps)
- - -
Beneficial insects (Predatory mites)
- - -
Beneficial insects (Ground beetles)
- - -
Aquatic ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Fish - Chronic 21 day NOEC (mg l⁻¹)
- - -
Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
> 131
R4 R = Peer reviewed scientific publications
4 = Verified data
Daphnia magna		 Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
- - -
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)
- - -
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
- - -
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
- - -
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
- - -
Mesocosm study data
NOEAEC mg l⁻¹
- - -
NOEAEC mg l⁻¹
- - -
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III) - -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 2000
Q3 Q = Miscellaneous internet resources
3 = Unverified data of known source
Mouse		 Low
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
- - -
Mammals - Inhalation LC₅₀ (mg l⁻¹)
- - -
Other Mammal toxicity endpoints
Subcutaneous LD₅₀ > 2000 mg kg⁻¹
V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM )
3 = Unverified data of known source
Rat		 -
Intravenous LD₅₀ = 2450 mg kg⁻¹
V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM )
3 = Unverified data of known source
Rabbit		 -
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
- - -
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
- - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)
- - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)
- - -
Dermal penetration studies (%)
- - -
Dangerous Substances Directive 76/464
- - -
Exposure Routes
Public
-
Occupational
-
Mammalian dose elimination route and rate
Partly metabolibised and eliminated predominately in urine with lesser amounts in faeces, bile and milk.
CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here )
3 = Unverified data of known source
 -
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
?Possibly, status not identified
A0 A = Chromosome aberration (EFSA database)
0 = No data
;
B0 B = DNA damage/repair (EFSA database)
0 = No data
;
C0 C = Gene mutation (EFSA database)
0 = No data
;
D0 D = Genome mutation (EFSA database)
0 = No data
;
E3 E = Unspecified genotoxicity type (miscellaneous data source)
3 = Negative
 No data found
Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant
✓Yes, known to cause a problem
 No data found
✓Yes, known to cause a problem
Respiratory tract irritant Skin irritant Skin sensitiser
✓Yes, known to cause a problem
?Possibly, status not identified
✓Yes, known to cause a problem
Eye irritant Phototoxicant  
✓Yes, known to cause a problem
 No data found  
General human health issues
Harmful if inhaled
may cause gastric irritation and vomiting
Possible liver and kidney toxicant
Handling issues
Property
Value and interpretation
General
Light sensitive
CLP classification 2013
-
WHO Classification
None - not a ppp
UN Number
-
Waste disposal & packaging
-
TRANSLATIONS
Language
Name
English
sulphadimidine
French
-
German
-
Danish
-
Italian
sulfametazina
Spanish
sulfadimidina
Greek
-
Polish
sulfametazina
Swedish
-
Hungarian
-
Dutch
-
Record last updated: 26/04/2021
Contact: aeru@herts.ac.uk
Please cite as: Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242