Cabergoline
Last updated: 08/04/2021
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Drug used to suppress lactation and treat phantom pregnancy in dogs
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1981, developed Italy
Dogs
Isomeric
C₂₆H₃₇N₅O₂
CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C
KORNTPPJEAJQIU-KJXAQDMKSA-N
InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
cabergoline
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Gynecological drug, Medicinal drug
Ergot derivative
98%
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Synthetic
A dopamine D2 receptor agonist; a potent prolactin inhibitor.
[D(2) dopamine receptor, agonist], [5-hydroxytryptamine 2B receptor, agonist], [D(3) dopamine receptor, agonist], [5-hydroxytryptamine 2A receptor, agonist], [Alpha-2B adrenergic receptor, antagonist], [5-hydroxytryptamine 1D receptor, agonist], [Alpha-2A adrenergic receptor, antagonist], [5-hydroxytryptamine 1A receptor, agonist], [Alpha-2C adrenergic receptor, antagonist], [D(1B) dopamine receptor, agonist], [D(1A) dopamine receptor, agonist], [5-hydroxytryptamine 1B receptor, agonist], [5-hydroxytryptamine 2C receptor, agonist], [5-hydroxytryptamine 7 receptor, antagonist]
81409-90-7
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QG02CB03
Genito urinary system & sex hormones: Other gynecologicals
No
No data
451.60
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N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]- 6-(2-propenyl)-8g-ergoline-8-carboxamide
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White powder
Galastop 50 µg/ml Oral solution
Ceva Vetem SpA
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
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103
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
6-allyl-8b-carboxy-ergoline (Ref: FCE 21589)
acid derivative
Animal; Human (Urine)
~0.3
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Ref: FCE 21904
amide derivative
Animal
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Ref: FCE 21590
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Animal (Urine)
Small quantity
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Terrestrial ecotoxicology
383
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Rat
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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383
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Rat
Moderate
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Rapidly and extensively metabolised in the liver and excreted mainly in faeces (rat data)
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
?Possibly, status not identified
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
Hormonal agent May cause gastric problems May cause nausea, vomiting, abdominal cramps, anorexia, diarrhoea, and constipation
No information available
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None - not a ppp
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cabergoline
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cabergolina
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Record last updated:
08/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242