Norfloxacin
Last updated: 22/04/2021
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Broad spectrum antiobiotic drug active against both Gram-positive and Gram-negative bacteria and used to treat urinary tract, respiratory and other infectious diseases
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1979, first patent
Sheep, Pigs, Dogs, cats
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C₁₆H₁₈FN₃O₃
CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O
No data
OGJPXUAPXNRGGI-UHFFFAOYSA-N
InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
norfloxacin
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Antibiotic, Antibacterial, Chemotherapy drug, Medicinal drug
Fluoroquinolone
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Synthetic
Inhibits bacterial DNA gyrase
[DNA topoisomerase 4 subunit A, antagonist], [DNA gyrase subunit A, antagonist], [DNA topoisomerase 2-alpha, antagonist]
70458-96-7
274-614-4
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QJ01MA06
Antiinfectants for systemic use: Antibacterials for systemic use
No
No data
319.33
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1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline-3-carboxylic acid
1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
Evidence of use in third world countries
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White to pale yellow crystalline powder
None identified
None known
No UK approval for use
Not applicable
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178000
High
980
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Methanol
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1900
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Ethanol
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5100
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Acetone
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5500
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Chloroform
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227
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8.51 X 1000
Calculated
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0.93
R4 R = Peer reviewed scientific publications 4 = Verified data
Low
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6.26
R4 R = Peer reviewed scientific publications 4 = Verified data
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pKa(2) = 8.75
9.00 X 10-08
Low volatility
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In NaOH: 274nm, 325nm, 336nm
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 4000
Rat
Low
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16.6
R4 R = Peer reviewed scientific publications 4 = Verified data
Selenastrum capricornutum
Low
4.01
R4 R = Peer reviewed scientific publications 4 = Verified data
Selenastrum capricornutum
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 4000
Rat
Low
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Subcutaneous LD₅₀ > 1500 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 245 mg kg⁻¹
Rat
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Eliminated through metabolism, biliary excretion, and renal excretion.
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
?Possibly, status not identified
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
Possible kidney, liver and renal toxicant
Hygroscopic in air
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Not listed (Not listed)
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norfloxacin
norfloxacine
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norfloxacino
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Record last updated:
22/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242