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Sulphadimethoxine
Last updated: 26/04/2021
(Also known as: sulfadimethoxine; sulfadimetoxin; SDM)

Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate Ecotoxicity Human health
Environmental fate
Moderate alert:
Drainflow: Slightly mobile
Warning:
Significant data are missing
Ecotoxicity
Low alert:
Fish acute ecotoxicity: Low; Daphnia acute ecotoxicity: Low
Warning:
Significant data are missing
Human health
High alert:
Reproduction/development effects
Warning:
Significant data are missing
GENERAL INFORMATION
Description
Broad spectrum drug used to treat a variety of infections including those of the respiratory tract, urinary tract and soft tissue infections. It is also used for the treatment of coccidiosis.
Availability status
-
Introduction & key dates
-
Examples of species treated
Dogs, Horses, Cattle, Birds, Cats, Dogs, Poultry, Pigs, Sheep
Chemical structure
Isomerism
-
Chemical formula
C₁₂H₁₄N₄O₄S
Canonical SMILES
COC1=NC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N)OC
Isomeric SMILES
No data
International Chemical Identifier key (InChIKey)
ZZORFUFYDOWNEF-UHFFFAOYSA-N
International Chemical Identifier (InChI)
InChI=1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
2D structure diagram/image available?
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name Relationship Link
sulphadimethoxine -
General status
Veterinary substance type
Antibiotic, Antibacterial, Antiprotozoal, Coccidiostat, Antiparasitic, Medicinal drug
Substance groups
Sulphonamide
Minimum active substance purity
-
Known relevant impurities
-
Substance origin
Synthetic
Mode of action
Inhibits the conversion of para-aminobenzoic acid to dihydrofolic acid and so inhibits bacterial synthesis
Molecular targets
[Cytochrome P450 2C9, inhibitor]
CAS RN
122-11-2
EC number
204-523-7
CIPAC number
-
US EPA chemical code
-
PubChem CID
-
ATCvet Code
QJ01EQ09; QP51AG02
Therapeutic Class
Antiinfectants for systemic use: Antibacterials for systemic use, Antiprotozoals
Controlled Drug?
No
Regulation 37/2010 MRL Classification
Allowed substance (Table 1: All food producing species)
Molecular mass
310.33
PIN (Preferred Identification Name)
-
IUPAC name
4-amino-N-(2,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
CAS name
4-amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzolsulfonamid
Other status information
-
Relevant Environmental Water Quality Standards
-
Physical state
White powder
Related substances & organisms
Formulations
Property
Product
Manufacturer
Authorisation Route
UK Legal Class
Example products using this active
Coxi Plus 25% w/w powder for oral solution Oropharma n.v. UK National authorisation Prescription only medicine to be authorised by a veterinarian (POM-V)
Formulation and application details
-
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
343
V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM )
3 = Unverified data of known source
Moderate
Solubility - In organic solvents at 20 °C (mg l⁻¹)
- - -
Melting point (°C)
200
Q3 Q = Miscellaneous internet resources
3 = Unverified data of known source
-
Boiling point (°C)
Decomposes before boiling
Q3 Q = Miscellaneous internet resources
3 = Unverified data of known source
-
Degradation point (°C)
- - -
Flashpoint (°C)
- - -
Octanol-water partition coefficient at pH 7, 20 °C
P
4.27 X 1000 Calculated -
Log P
0.63
R4 R = Peer reviewed scientific publications
4 = Verified data
Low
Fat solubility of residues
Solubility
- - -
Data type
- - -
Density (g ml⁻¹)
- - -
Dissociation constant pKa) at 25 °C
5.54
R4 R = Peer reviewed scientific publications
4 = Verified data
-
-
Vapour pressure at 20 °C (mPa)
2.11 X 10-04
R4 R = Peer reviewed scientific publications
4 = Verified data
Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
- - -
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
- - -
Surface tension (mN m⁻¹)
- - -
Refractive Index
- - -
Degradation
Property
Value
Source; quality score; and other information
Interpretation
Soil degradation (days) (aerobic)
DT₅₀ (typical)
- - -
DT₅₀ (lab at 20 °C)
- - -
DT₅₀ (field)
- - -
DT₉₀ (lab at 20 °C)
- - -
DT₉₀ (field)
- - -
Note
-
Manure DT₅₀ (days)
- - -
Aqueous photolysis DT₅₀ (days) at pH 7
Value
- - -
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
- - -
Note
-
Water-sediment DT₅₀ (days)
- - -
Water phase only DT₅₀ (days)
- - -
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd
-
R4 R = Peer reviewed scientific publications
4 = Verified data
Slightly mobile
Koc
1672
Notes and range
Koc 2517 mL g⁻¹ soil with 81.5% sand, 4856 mL g⁻¹ soil with 52% sand
Freundlich
Kf
- - -
Kfoc
-
1/n
-
Notes and range
-
pH sensitivity
-
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
- - -
Bio-concentration factor
BCF (l kg⁻¹)
- - -
CT₅₀ (days)
- -
Known metabolites

None

ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 1000
E3 E = Manufacturers safety data sheets
3 = Unverified data of known source
Rabbit
Moderate
Mammals - Short term dietary NOEL
(mg kg⁻¹)
- - -
(ppm diet)
- -
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
- - -
Birds - Acute LD₅₀ (mg kg⁻¹)
- - -
Birds - Short term dietary (LC₅₀/LD₅₀)
- - -
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
- - -
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
- - -
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
- - -
Soil micro-organisms
- - -
Collembola
Acute LC₅₀ (mg kg⁻¹)
- - -
Chronic NOEC (mg kg⁻¹)
- - -
Non-target plants
- - -
- - -
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Chronic
- - -
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Other pollinators (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Other pollinators (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Beneficial insects (Ladybirds)
- - -
Beneficial insects (Lacewings)
- - -
Beneficial insects (Parasitic wasps)
- - -
Beneficial insects (Predatory mites)
- - -
Beneficial insects (Ground beetles)
- - -
Aquatic ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
> 1000
R4 R = Peer reviewed scientific publications
4 = Verified data
Danio rerio other data: 400mg l⁻¹ Salmo
Low
Fish - Chronic 21 day NOEC (mg l⁻¹)
- - -
Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
189
R4 R = Peer reviewed scientific publications
4 = Verified data
Daphnia magna
Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
- - -
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)
- - -
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
- - -
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
2.3
R4 R = Peer reviewed scientific publications
4 = Verified data
Selenastrum capricornutum
Moderate
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
> 0.53
R4 R = Peer reviewed scientific publications
4 = Verified data
Selenastrum capricornutum
Moderate
Mesocosm study data
NOEAEC mg l⁻¹
- - -
NOEAEC mg l⁻¹
- - -
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III) - -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 1000
E3 E = Manufacturers safety data sheets
3 = Unverified data of known source
Rabbit
Moderate
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
- - -
Mammals - Inhalation LC₅₀ (mg l⁻¹)
- - -
Other Mammal toxicity endpoints
Intravenous LD₅₀ = 1000 mg kg⁻¹
V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM )
3 = Unverified data of known source
Rabbit
-
Subcutaneous LD₅₀ = 791 mg kg⁻¹
V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM )
3 = Unverified data of known source
Mouse
-
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
- - -
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
- - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)
- - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)
- - -
Dermal penetration studies (%)
- - -
Dangerous Substances Directive 76/464
- - -
Exposure Routes
Public
-
Occupational
-
Mammalian dose elimination route and rate
Metabolised and excreted mainly in the urine
Q3 Q = Miscellaneous internet resources
3 = Unverified data of known source
-
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database)
0 = No data
;
B0 B = DNA damage/repair (EFSA database)
0 = No data
;
C0 C = Gene mutation (EFSA database)
0 = No data
;
D0 D = Genome mutation (EFSA database)
0 = No data
;
E0 E = Unspecified genotoxicity type (miscellaneous data source)
0 = No data
No data found
Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant
Yes, known to cause a problem
No data found No data found
Respiratory tract irritant Skin irritant Skin sensitiser
Yes, known to cause a problem
Yes, known to cause a problem
No data found
Eye irritant Phototoxicant  
Yes, known to cause a problem
No data found  
General human health issues
May cause vomiting and diarrhoea
Possible kidney and liver toxicant
Handling issues
Property
Value and interpretation
General
Hygroscopic
CLP classification 2013
-
WHO Classification
None - not a ppp
UN Number
-
Waste disposal & packaging
-
TRANSLATIONS
Language
Name
English
sulphadimethoxine
French
-
German
-
Danish
-
Italian
sulfadimetossina
Spanish
sulfametoxina
Greek
-
Polish
-
Swedish
-
Hungarian
-
Dutch
-

Record last updated: 26/04/2021
Contact: aeru@herts.ac.uk
Please cite as: Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242