Sulphadimethoxine
Last updated: 26/04/2021
(Also known as: sulfadimethoxine; sulfadimetoxin; SDM)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Broad spectrum drug used to treat a variety of infections including those of the respiratory tract, urinary tract and soft tissue infections. It is also used for the treatment of coccidiosis.
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Dogs, Horses, Cattle, Birds, Cats, Dogs, Poultry, Pigs, Sheep
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C₁₂H₁₄N₄O₄S
COC1=NC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N)OC
No data
ZZORFUFYDOWNEF-UHFFFAOYSA-N
InChI=1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
sulphadimethoxine
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Antibiotic, Antibacterial, Antiprotozoal, Coccidiostat, Antiparasitic, Medicinal drug
Sulphonamide
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Synthetic
Inhibits the conversion of para-aminobenzoic acid to dihydrofolic acid and so inhibits bacterial synthesis
[Cytochrome P450 2C9, inhibitor]
122-11-2
204-523-7
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QJ01EQ09; QP51AG02
Antiinfectants for systemic use: Antibacterials for systemic use, Antiprotozoals
No
Allowed substance (Table 1: All food producing species)
310.33
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4-amino-N-(2,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
4-amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzolsulfonamid
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White powder
Coxi Plus 25% w/w powder for oral solution
Oropharma n.v.
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
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343
Moderate
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200
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Decomposes before boiling
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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4.27 X 1000
Calculated
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0.63
R4 R = Peer reviewed scientific publications 4 = Verified data
Low
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5.54
R4 R = Peer reviewed scientific publications 4 = Verified data
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2.11 X 10-04
R4 R = Peer reviewed scientific publications 4 = Verified data
Low volatility
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Soil adsorption and mobility
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R4 R = Peer reviewed scientific publications 4 = Verified data
Slightly mobile
1672
Koc 2517 mL g⁻¹ soil with 81.5% sand, 4856 mL g⁻¹ soil with 52% sand
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None
Terrestrial ecotoxicology
> 1000
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rabbit
Moderate
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> 1000
R4 R = Peer reviewed scientific publications 4 = Verified data
Danio rerio other data: 400mg l⁻¹ Salmo
Low
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189
R4 R = Peer reviewed scientific publications 4 = Verified data
Daphnia magna
Low
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2.3
R4 R = Peer reviewed scientific publications 4 = Verified data
Selenastrum capricornutum
Moderate
> 0.53
R4 R = Peer reviewed scientific publications 4 = Verified data
Selenastrum capricornutum
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 1000
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rabbit
Moderate
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Intravenous LD₅₀ = 1000 mg kg⁻¹
Rabbit
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Subcutaneous LD₅₀ = 791 mg kg⁻¹
Mouse
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Metabolised and excreted mainly in the urine
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause vomiting and diarrhoea Possible kidney and liver toxicant
Hygroscopic
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Not listed (Not listed)
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sulphadimethoxine
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sulfadimetossina
sulfametoxina
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Record last updated:
26/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242