Tricaine mesylate
Last updated: 26/04/2021
(Also known as: tricaine methane sulphonate; tricaine methane sulfonate; MS222; TMS; tricaine mesilate)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A drug used for anesthesia, sedation or euthanasia of fish
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Fish
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C₁₀H₁₅NO₅S
CCOC(=O)C1=CC(=CC=C1)N.CS(=O)(=O)O
No data
FQZJYWMRQDKBQN-UHFFFAOYSA-N
InChI=1S/C9H11NO2.CH4O3S/c1-2-12-9(11)7-4-3-5-8(10)6-7;1-5(2,3)4/h3-6H,2,10H2,1H3;1H3,(H,2,3,4)
Yes
Anesthetic, Muscle relaxant, Medicinal drug
Unclassified substance
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Synthetic
Acts by preventing action potentials and so as no signals care exchanged between the brain and the extremities organs cease to operate
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886-86-2
212-956-8
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QN01AX93
Nervous system: Anesthetics
No
Allowed substance (Table 1: Fin fish)
261.30
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ethyl 3-aminobenzoate methanesulfonic acid
ethyl-m-aminobenzoate methanesulfonate
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Fine, white, odourless crystalline powder
MS222 100% w/w Powder for Solution for Fish Treatment
Pharmaq Ltd
UK National authorisation
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Usually supplied as a water additive
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149.5
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Decomposes before boiling
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 5200
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Rat
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 5200
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Rat
Low
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Intravenous LD₅₀ > 180 mg kg⁻¹
Mouse
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Can be absorbed through the skin
In fish it is rapidly metabolised primarily by the liver but also in the kidneys, blood, metabolites then are excreted through the gills and liver
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause skin irritation, resulting in reddening, itching, and inflammation
No information available
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None - not a ppp
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tricaine mesylate
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Record last updated:
26/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242