Propofol
Last updated: 21/06/2023
(Also known as: penguin milk; ICI35868; diisopropylphenol ; disoprofol)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A drug used to induce and maintain general anesthesia and for procedural sedation
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1977
Cats, Dogs, Small domestic animals
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C₁₂H₁₈O
CC(C)C1=C(C(=CC=C1)C(C)C)O
No data
OLBCVFGFOZPWHH-UHFFFAOYSA-N
InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
propofol
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Sedative, Anesthetic
Alkylphenol
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Synthetic
Potentiation of GABA-A receptor activity
[Gamma-aminobutyric-acid (GABA) receptor subunit beta-2, potentiator], [Gamma-aminobutyric-acid (GABA) receptor subunit beta-3, potentiator], [Sodium channel protein type 4 subunit alpha, antagonist], [Sodium channel protein type 2 subunit alpha, antagonist]
2078-54-8
218-206-6
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QN01AX10
Nervous system: Anaesthetics
No
No data
178.27
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2,6-diisopropylphenol
2,6-bis(1-methylethyl)phenol
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White to pale yellow coloured oil
Norofol 1% w/v Emulsion for Injection
Norbrook Labs
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Procare 1% w/v Emulsion for Injection
Norbrook Labs
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
PropoFlo Plus 10mg/ml Emulsion for Injection
Abbott Labs Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
PropoFlo Vet 10mg/ml Emulsion for Injection
Abbott Labs Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as an injectable emulsion
124
Moderate
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18
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256
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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112
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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6.17 X 1003
Calculated
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3.79
High
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0.955
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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11.1
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Soil adsorption and mobility
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Slightly mobile
2700
Estimated
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Known soil and groundwater metabolites
None
4-hydroxypropofol
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Human (Liver)
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Cytochrome P450 2C9 Cytochrome P450 2B6
propofol glucuronide
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Human (Liver)
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UDP-glucuronosyltransferase 1-8 UDP-glucuronosyltransferase 1-9
Terrestrial ecotoxicology
500
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Moderate
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HUMAN HEALTH AND PROTECTION
Low (class I)
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500
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Moderate
2000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rabbit
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Intravenous LD₅₀ = 42 mg kg⁻¹
Rat
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Intraperitoneal LD₅₀ = 170 mg kg⁻¹
Mouse
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Around 70% of a dose is excreted in the urine within 24hrs after administration and 90% within 5days
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
No information available
Corrosive IMDG Transport Hazard Class 8
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Not listed (Not listed)
UN2922
Packaging Group III (minor danger)
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propofol
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Record last updated:
21/06/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242