The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Human health High alert: Reproduction/development effects; Neurotoxicant
GENERAL INFORMATION
Description
Drug used to treat behavioural problems, including aggression and obsessive compulsive behavious, in cats, dogs and other animals
Availability status
-
Introduction & key dates
circa 1970 discovered; 1977 introduced to market
Examples of species treated
Cats, Dogs, Caged birds
Chemical structure
Isomerism
Fluoxetine has a chiral center giving two enantiomers, R-fluoxetine and S-fluoxetine. The two enantiomers of fluoxetine are similarly effective in blocking serotonin reuptake. Technical materrial is an isomeric mixture.
A0 A = Chromosome aberration (EFSA database) 0 = No data
;
B0 B = DNA damage/repair (EFSA database) 0 = No data
;
C0 C = Gene mutation (EFSA database) 0 = No data
;
D0 D = Genome mutation (EFSA database) 0 = No data
;
E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
General human health issues
May cause sexual dysfunction Possible liver toxicant May cause drowsiness, tremor, headache, dizziness and blurred vision May cause nausea, vomiting and abdominal pain
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242