Betamethasone
Last updated: 07/04/2021
(Also known as: betadexamethasone; betafluorene)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Mainly used to treat skin irritations and infections in dogs
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Dogs
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C₂₂H₂₉FO₅
CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
UREBDLICKHMUKA-DVTGEIKXSA-N
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
Yes
Anti-inflammatory, Immunosuppressant
Corticosteroid
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Synthetic
Modifies the levels and array of proteins synthesised by the various target tissues
[Glucocorticoid receptor, agonist]
378-44-9
206-825-4
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QD07CC01; QH02AB01; QS02CA90
Dermatologicals: Corticosteriods, dermatological preparations; Systemic hormone preparations excluding sex hormones & insulin: Corticosteroids for systemic use; Sensory organs: Otologicals
No
Allowed substance (Table 1: Bovine, Porcine)
392.46
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(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro- 3H-cyclopenta[a]phenanthren-3-one
1-dehydro-9-fluoro-17-hydroxy-16β-methyl-corticosterone
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Cream coloured crystalline powder
Fuciderm Gel
Dechra Veterinary Products A/S
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Norbet 0.25 mg Tablets
Norbrook Labs
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Otomax Ear Drops Suspension
Schering-Plough Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
It is applied as a topical cream, ointment, foam, lotion, gel or by local injection
65.5
Moderate
160000
Methanol
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232
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Decomposes before boiling
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232
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8.71 X 1001
Calculated
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1.94
Low
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13.48
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Methanol: 238nm = 15200
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 4500
Mouse
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 4500
Mouse
Low
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Metabolised end excreted in the urine
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause perioral or allergic contact dermatitis
No information available
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None - not a ppp
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betamethasone
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betametasona
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Record last updated:
07/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242