Isoxsuprine
Last updated: 15/04/2021
(Also known as: vasosurpine)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A drug used to most commonly used to treat hoof-related problems in horses, particularly laminitis and navicular disease
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Horses
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C₁₈H₂₃NO₃
CC(COC1=CC=CC=C1)NC(C)C(C2=CC=C(C=C2)O)O
No data
BMUKKTUHUDJSNZ-UHFFFAOYSA-N
InChI=1S/C18H23NO3/c1-13(12-22-17-6-4-3-5-7-17)19-14(2)18(21)15-8-10-16(20)11-9-15/h3-11,13-14,18-21H,12H2,1-2H3
Yes
Vasodilator, Medicinal drug
Unclassified substance
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Synthetic
Causes peripheral and cerebral vasodilatation by directly acting on vascular smooth muscle.
[Alpha-receptor, antagonist], [Beta-adrenergic, agonist]
395-28-8
206-898-2
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QC04AA01
Cardiovascular system: Peripheral vasodilators
No
Allowed substance (Table 1: Bovine, Equidae)
301.38
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4-{1-hydroxy-2-[(1-methyl-2-phenoxyethyl)amino]propyl}phenol
p-hydroxy-N-(1-methyl-2-phenoxyethyl)norephedrine
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White crystalline powder
Navilox 3% w/w powder for in-feed use
Vétoquinol UK Limited
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Oralject Circulon Brand Paste
Vetsearch International Pty Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as medicated feed additives or in oral paste formulations
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103
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2.24 X 1002
Calculated
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2.35
Low
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
200
Mouse
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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200
Mouse
Moderate
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Intraperitoneal LD₅₀ = 118 mg kg⁻¹
Mouse
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Intravenous LD₅₀ = 48 mg kg⁻¹
Mouse
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Almost completely absorbed from the gastrointestinal tract and excreted in the urine
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause dizziness, flushing, stomach upset, nausea, shaking or nervousness Harmful if ingested May cause dermatitus
No information available
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Not listed (Not listed)
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isoxsuprine
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isoxsuprina
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Record last updated:
15/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242