Fentanyl
Last updated: 24/06/2022
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A potent class-II narcotic analgesic used as an anesthetic and analgesic for various surgical procedures
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1960, first synthesised
Sheep, Goats, Dogs, Cats, Bears, Pigs, Rats, Mice, Rabbits
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C₂₂H₂₈N₂O
CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3
No data
PJMPHNIQZUBGLI-UHFFFAOYSA-N
InChI=1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
fentanyl
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fentanyl citrate
Variant
Analgesic, Anesthetic, Medicinal drug
Synthetic opioid
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Synthetic
A mu-opioid agonist
[Mu-type opioid receptor, agonist], [Delta-type opioid receptor, agonist], [Kappa-type opioid receptor, agonist]
437-38-7
207-113-6
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QN01AH51
Nervous system: Anesthetics
Yes, Class 2
No data
336.47
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N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide
1-phenethyl-4-(phenylproprionylamino)piperidine
USA Superlist DEA Schedule II
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White crystalline powder
Hypnorm Solution for Injection
Abbeyvet Export Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Innovar Vet solution for injection
Janssen
No UK authorisation for use with animals
Not applicable
Formulated for intravenous use
200
Moderate
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87
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1.12 X 1004
Calculated
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4.05
High
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7.3
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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pKa(2) = 8.41
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
norfentanyl Note: Pharmacologically inactive
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Human (Liver)
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Cytochrome P450 3A4
4-N-anilinopiperidine
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Hydrolysis
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propionic acid
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Hydrolysis
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Terrestrial ecotoxicology
3.1
Rat
High
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HUMAN HEALTH AND PROTECTION
High (class III)
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3.1
Rat
High
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Subcutaneous LD₅₀ = 1.5 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 2.91 mg kg⁻¹
Rat
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May be absorbed through dermal contact
Considerable metabolism, up to 75% excreted as metabolites in the urine, less lost via the faeces, <10% unchnaged
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause diarrhoea, nausea, constipation, dry mouth, somnolence and confusion May cause respiratory depression
No information available
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None - not a ppp
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fentanyl
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fentanila
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Record last updated:
24/06/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242