Selegiline hydrochloride
Last updated: 21/06/2023
(Also known as: selegiline; selegiline HCl; R-selegiline hydrochloride; L-deprenyl; L-deprenalin)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A complex drug used to treat age-related neurological (behavioural and emotional) conditions mainly in dogs
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Dogs, Cats
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C₁₃H₁₈NCl
CC(CC1=CC=CC=C1)N(C)CC#C.Cl
C[C@H](CC1=CC=CC=C1)N(C)CC#C.Cl
IYETZZCWLLUHIJ-UTONKHPSSA-N
InChI=1S/C13H17N.ClH/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13;/h1,5-9,12H,10-11H2,2-3H3;1H/t12-;/m1./s1
Yes
Medicinal drug
Phenethylamine
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Synthetic
Monoamine Oxidase B Inhibitor, increases dopamine - a nervous system chemical messenger
[Amine oxidase (flavin-containing) B, antagonist], [Amine oxidase (flavin-containing) A, inhibitor]
14611-52-0
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QN06AX90
Nervous system: Psychoanaleptics
No
No data
223.5
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(R)-N,α-dimethyl-N-2-propynyl-benzeneethanamine hydrochloride
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Marine pollutant
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White crystalline powder
Selgian 10 mg film-coated tablets
Ceva Sante Animale
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Selgian 20 mg film-coated tablets
Ceva Sante Animale
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Selgian 4 mg film-coated tablets
Ceva Sante Animale
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied in tablet form for oral administration
10
Low
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141
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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272.5
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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108.4
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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7.94 X 1002
Calculated
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2.9
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Moderate
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
N-desmethylselegiline Note: Also brain activity stimulant
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Human/Animal (Urine)
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L-methamphetamine Note: Also brain activity stimulant
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Human/Animal (Urine)
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Terrestrial ecotoxicology
385
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Moderate
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9.9
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Danio rerio
Moderate
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33.4
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Daphnia magna
Moderate
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65.0
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Green algae
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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385
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Moderate
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Subcutaneous LD₅₀ = 280 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 81 mg kg⁻¹
Rat
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Extensively metabolised which are excreted mainly in the urine
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May cause cardiovascular, respiratory and gastrointestinal problems
IMDG Transport Hazard Class 6.1
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Not listed (Not listed)
UN3249
Packaging Group III (minor danger)
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selegiline hydrochloride
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selegilina
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Record last updated:
21/06/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242