Azaperone
Last updated: 21/06/2023
(Also known as: fluoperidol; stresnil)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A sedative drug used mainly to control aggressiveness
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Pigs, Elephants
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C₁₉H₂₂FN₃O
C1CN(CCN1CCCC(=O)C2=CC=C(C=C2)F)C3=CC=CC=N3
No data
XTKDAFGWCDAMPY-UHFFFAOYSA-N
InChI=1S/C19H22FN3O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15H2
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
azaperone
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Sedative, Anesthetic, Tranquiliser, Medicinal drug
Pyridinylpiperazine
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Synthetic
A dopamine antagonist producing a strong anticholinergic effect
[D(2) dopamine receptor, antagonist]
1649-18-9
216-715-8
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QN01AX91, QN05AD90
Nervous system: Anesthetics; Psycholeptics
No
Allowed substance (Table 1: Porcine)
327.40
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1-(4-fluorophenyl)-4-(4-pyridin-2-ylpiperazin-1-yl)butan-1-one
4'-fluoro-4-(4-(2-pyridyl)-1-piperazinyl)butyrophenone
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White to yellowish-white crystalline powder
Stresnil 40 mg/ml Solution for Injection for Pigs
Janssen-Cilag Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as a solution for injection
50
Moderate
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92
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2.00 X 1003
Calculated
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3.3
High
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7.5
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pKa(2) = 4.3
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Max at 243nm and 312nm
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
245
Rat
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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245
Rat
Moderate
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Subcutaneous LD₅₀ = 450 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 25 mg kg⁻¹
Rat
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Extensively metabolised and extreted in the urine (20-25%) and faeces (60-80%)
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May cause hypotension & behavioural problems Possible respiratory depressant Possible liver, heart and kidney toxicant
IMDG Transport Hazard Class 6.1
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Not listed (Not listed)
UN2811
Packaging Group III (minor danger)
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azaperone
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azaperona
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Record last updated:
21/06/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242