Tepoxaline
Last updated: 26/04/2021
(Also known as: tepoxalin)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A non-steroidal anti-inflammatory drug (NSAID) used to treat the pain and inflammation of osteoarthritis
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Dogs
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C₂₀H₂₀ClN₃O₃
CN(C(=O)CCC1=NN(C(=C1)C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)OC)O
No data
XYKWNRUXCOIMFZ-UHFFFAOYSA-N
InChI=1S/C20H20ClN3O3/c1-23(26)20(25)12-7-16-13-19(14-3-5-15(21)6-4-14)24(22-16)17-8-10-18(27-2)11-9-17/h3-6,8-11,13,26H,7,12H2,1-2H3
Yes
Anti-inflamatory, Medicinal drug
Unclassified substance
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Synthetic
Thought to have dual action acting through the inhibition of cyclooxygenase activity and the inhibition of lipoxygenase.
[Prostaglandin G/H Synthase 1, antagonist], [5-lipoxygenase, antagonist]
103475-41-8
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QM01AE92
Musculo-skeletal system: Anti-inflammatory and antirheumatic products
No
No data
385.85
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3-(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl)-N-hydroxy-N-methylpropanamide
5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide
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White crystalline solid
Zubrin 100mg Oral Lyophilisates for Dogs
Schering-Plough Ltd
EU Centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Zubrin 200mg Oral Lyophilisates for Dogs
Schering-Plough Ltd
EU Centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Supplied in tablet form for oral administration
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128
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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573
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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300
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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1.26
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
tepoxalin acid Note: Pharmacologically active
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Animal
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Terrestrial ecotoxicology
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HUMAN HEALTH AND PROTECTION
High (class III)
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Rapidly metabolised, the metabolites are eliminated almost entirely in the faeces
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May cause gastrointestinal problems May cause lethagy, incoordination, seizures, or behavioral changes
No information available
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Not listed (Not listed)
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tepoxaline
tepoxaline
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tepoxalina
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Record last updated:
26/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242