Clenbuterol
Last updated: 02/03/2022
(Also known as: clen; angel dust; clenbuteroleum)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Drug used as a decongestant and bronchodilator to treat breathing disorders and as a smooth muscle relaxant
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Horses, Cattle
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C₁₂H₁₈Cl₂N₂O
CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O
No data
STJMRWALKKWQGH-UHFFFAOYSA-N
InChI=1S/C12H18Cl2N2O/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7/h4-5,10,16-17H,6,15H2,1-3H3
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
clenbuterol
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Muscle relaxant, Bronchodilator agent, Thermogenic drug, Medicinal drug
Amine
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Synthetic
Steroid like action, induces activation of adenylate cyclase through the action of G proteins. A beta-2 selective adrenergic agonist
[Beta-2 adrenergic receptor, agonist], [Beta-1 adrenergic receptor, agonist], [Beta-3 adrenergic receptor, agonist], [Beta-nerve growth factor, stimulator], [Tumor necrosis factor]
37148-27-9
253-366-0
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QG02CA91; QR03CC13
Genito urinary system & sex hormones: Other gynecologicals; Respiratory system: Drugs for obstructive airway diseases
Yes (class 4)
Allowed substance (Table 1: Bovine, Equidae)
277.19
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(RS)-1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol
1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethan-1-ol
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White to pale yellow crystalline powder
Planipart Solution for Injection 30 mg/l
Boehringer Ingelheim Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Ventipulmin Granules 16 mg/l
Boehringer Ingelheim Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Ventipulmin Solution for injection 30mg/l
Boehringer Ingelheim Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Ventipulmin Syrup 25 mg/l
Boehringer Ingelheim Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Various formulations are available for both oral and intravenous administration
112
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Moderate
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8.71 X 1002
Calculated
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2.94
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Moderate
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17.84
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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73.38
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
159
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Rat as the hydrochloride
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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159
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Rat as the hydrochloride
Moderate
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Intravenous LD₅₀ = 27.6 mg kg⁻¹
Mouse
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May be absorbed through the skin
Major fraction of the drug is excreted into the urine
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Very toxic Possible liver and cardiovascular toxicant May cause muscle tremor, headache, dizziness and gastric irritation May cause hypotension
IMDG Transport Code is usually 6.1 for products
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None - not a ppp
2811 for hydrochloride product
Packaging Group II (medium danger)
clenbuterol
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Record last updated:
02/03/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242