Ethinyl estradiol
Last updated: 24/06/2022
(Also known as: ethinyl estradiol; EE; aethinyloestradiolum; etinilestradiol; 17alpha-ethinyloestradiol)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A prescription drug that is used to start the heat cycle in horses and to prevent pregnancy in cats and dogs
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1943, USA
Dogs, Cats, Horses
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C₂₀H₂₄O₂
CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)O
BFPYWIDHMRZLRN-SLHNCBLASA-N
InChI=1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
ethinyl estradiol hemihydrate
Variant
Contraceptive, Hormone therapy, Medicinal drug
Oestrogen
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Semi-synthetic
Diffuses into the target cells and interacts with a protein receptor
[Estrogen receptor, agonist], [Orphan nuclear receptor PXR, agonist]
57-63-6
200-342-2
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QG03CA03
Genito urinary system & sex hormones: Sex hormones & modulators of the genital system
No
No data
296.40
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19-nor-17α-pregna-1,3,5(10)-trien-20-yne-3,17-diol
(17-α)-19-norpregna-1,3,5(10)-trien-20-yne-3,17,diol
Found in water bodies
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Creamy coloured solid
None identified
None identified
No UK authorisation for use with animals
Not applicable
Usually administered orally
4.8
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Low
166
Ethanol
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250
Ether
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200
Acetone
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50
Chloroform
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183
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Decomposes before boiling
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1.41 X 1004
Calculated
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4.15
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
High
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10.21
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
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87.37
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
2-methoxyethinylestradiol
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Rat (Liver)
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2-hydroxyethinylestradiol-3-methy1 ether
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Rat (Liver)
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2-hydroxyethinylestradiol Note: Main metabolic product in liver
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Rats (liver); Human (Liver)
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Cytochrome P450 3A4
Terrestrial ecotoxicology
1737
Rat
Moderate
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1.61
R4 R = Peer reviewed scientific publications 4 = Verified data
Pimephales promelas
Moderate
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6.4
R4 R = Peer reviewed scientific publications 4 = Verified data
Daphnia magna
Moderate
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0.84
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Unknown species
Moderate
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HUMAN HEALTH AND PROTECTION
Intermediate (class II)
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1737
Rat
Moderate
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Subcutaneous LD₅₀ > 2000 mg kg⁻¹
Rat
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Intraperitoneal LD₅₀ = 471 mg kg⁻¹
rat
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Metabolised in the liver and excreted in the faeces, urine and, in small amounts, in milk
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
✓Yes, known to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E2 E = Unspecified genotoxicity type (miscellaneous data source) 2 = Mixed/ambiguous results
?Possibly, status not identified
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
?Possibly, status not identified
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
May cause gastointestinal problems May cause jaundice, hypertension, nasal congestion, headache, dizziness and fluid retention
May react vigorously with strong oxidizing and reducing agents
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None - not a ppp
Not regulated
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ethinyl estradiol
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Aethinyoestradiol
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etinilestradiol
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Record last updated:
24/06/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242