Pimobendan
Last updated: 03/08/2022
(Also known as: pimobendane; dl-pimobendan)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A drug used to treat congestive heart disease mainly in dogs and cats
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Dogs, Cats
Isomeric
C₁₉H₁₈N₄O₂
CC1CC(=O)NN=C1C2=CC3=C(C=C2)N=C(N3)C4=CC=C(C=C4)OC
No data
GLBJJMFZWDBELO-UHFFFAOYSA-N
InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
pimobendan
Unstated isomer
(RS)-pimobendan monohydrate
monohydrate
Cardiovascular Agent, Medicinal drug
Benzimidazole
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Synthetic
A calcium sensitiser with positive inotropic and vasodilator effects and also a selective inhibitor of phosphodiesterase III (PDE3).
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74150-27-9
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QC01CE90
Cardiovascular system: Cardiac therapy
No
No data
334.37
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4,5-dihydro-6-(2-(4-methoxyphenyl)-1H-benzimidazol-5-yl)-5-methyl-3(2H)-pyridazinone
(RS)-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
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Vetmedin 1.25 mg Flavour Tablets
Boehringer Ingelheim
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Vetmedin 1.25 mg Hard Capsules
Boehringer Ingelheim
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually administered orally as tablets or capsules
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1.36
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
950
Rat
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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950
Rat
Moderate
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Subcutaneous LD₅₀ > 300 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 72 mg kg⁻¹
Rat
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Elimination is first via excretion in the bile and then faeces
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
?Possibly, status not identified
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
Possible endocrine toxicant
No information available
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Not listed (Not listed)
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pimobendan
pimobendane
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pimobendan
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Record last updated:
03/08/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242