Levofloxacin
Last updated: 21/04/2021
(Also known as: efloxacin; (S)-(-)-ofloxacin ; levofloxacin; L-ofloxacin)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A broad-spectrum antibiotic active against both Gram-positive and Gram-negative bacterial infections
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1987, first patented USA
Poultry, Dogs, Cats
Isomeric
C₁₈H₂₀FN₃O₄
CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
GSDSWSVVBLHKDQ-JTQLQIEISA-N
InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
levofloxacin
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Antibiotic, Bactericide, Antimicrobial, Medicinal drug
Fluoroquinolone
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Synthetic
Inhibits DNA gyrase
[DNA topoisomerase 4 subunit A, antagonist], [DNA gyrase subunit A, antagonist], [DNA topoisomerase 2-alpha, antagonist]
100986-85-4
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QJ01MA12
Antiinfectants for systemic use: Antibacterials for systemic use
No
No data
361.37
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(S)-7-fluoro-6-(4-methylpiperazin-1-yl) -10-oxo-4-thia-1-azatricyclo[7.3.1.05,13] trideca-5(13),6,8,11-tetraene-11-carboxylic acid
(S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl) -7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij] quinoline-6-carboxylic acid
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Solid
None identified
None identified
No UK authorisation for use with animals
Not applicable
Available in a range of formulations for oral, intravenous and topical use
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225
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
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1.26 X 1002
Calculated
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2.1
Low
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
1478
Rat
Moderate
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> 100
R4 R = Peer reviewed scientific publications 4 = Verified data
Oryzias latipes
Low
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0.34
R4 R = Peer reviewed scientific publications 4 = Verified data
Daphnia magna
Moderate
0.063
R4 R = Peer reviewed scientific publications 4 = Verified data
Daphnia magna
Moderate
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1.2
R4 R = Peer reviewed scientific publications 4 = Verified data
Pseudokirchneriella subcapitata
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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1478
Rat
Moderate
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65 - 80% of administered oral dose is excreted unchanged via the kidneys within 48 hours of dosing, <8% is excreted in the faeces. These is also a small amount of bilary excretion.
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E1 E = Unspecified genotoxicity type (miscellaneous data source) 1 = Positive
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
?Possibly, status not identified
 
May cause tendon deterioration May cause serious psychiatric side effects May cause sunlight sensitivity
No information available
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None - not a ppp
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levofloxacin
levofloxacine
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levofloxacino
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Record last updated:
21/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242