Lidocaine
Last updated: 16/03/2023
(Also known as: lignocaine; xylestesin)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A drug commonly used as a topical and local anesthetic
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1943, first synthesised
Cats, Dogs, Cattle, Horses, Sheep, Pigs
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C₁₄H₂₂N₂O
CCN(CC)CC(=O)NC1=C(C=CC=C1C)C
No data
NNJVILVZKWQKPM-UHFFFAOYSA-N
InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
lidocaine
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Anaesthetic, Medicinal drug
Unclassified substance
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Synthetic
Acts as a sodium channel blocker
[Sodium channel protein type 10 subunit alpha, antagonist], [Sodium channel protein type 9 subunit alpha, antagonist], [Sodium channel protein type 5 subunit alpha, antagonist], [Epidermal growth factor receptor, antagonist]
137-58-6
205-302-8
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QN01BB52; QD08AE99
Nervous system: Anaesthetic; Dermatologicals: Antiseptics & disinfectants
No
Allowed substance (Table 1: Equidae)
234.34
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2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
N-(2,6-dimethylphenyl)-N2,N2-diethylglycinamide
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White to slightly yellow coloured crystalline powder
Lignocaine and Adrenaline Solution for Injection
Norbrook Labs
UK National authorisation
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Intubeaze 20 mg/ml Oromucosal spray
Dechra Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Locaine 2% w/v Solution for injection
Norbrook Labs
UK National authorisation (IC)
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Otodex skin cream
Petlife International Ltd
UK National authorisation
Authorised veterinary medicine for general sale (AVM - GSL)
Supplied in a variety of formulations including creams and gels for topical application and solutions for injection
4100
High
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68.5
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181
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2.75 X 1002
Calculated
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2.44
Low
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7.86
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0.144
Low volatility
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Soil adsorption and mobility
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Low risk
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Based on LogP < 3
Low risk
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Known soil and groundwater metabolites
None
monoethylglycinexylidide Note: Pharmacologically active
MEGX
Human (Liver)
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Cytochrome P450 1A2 Cytochrome P450 3A4
N,N-diethylglycine-3-hydroxy-2,6,xylidide Note: Pharmacologically active
glycine xylidide
Human (Liver); Rat
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Cytochrome P450 1A2 Cytochrome P450 3A4
4-hydroxy-2,6-dimethylaniline
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Human
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Terrestrial ecotoxicology
317
Rat
Moderate
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106
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Danio rerio as LC0
Low
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112
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Daphnia magna
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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317
Rat
Moderate
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Subcutaneous LD₅₀ = 335 mg kg⁻¹
Rat
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Intraperitoneal LD₅₀ = 133 mg kg⁻¹
Rat
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In humans & dogs, rapidly metabolised in the liver & around 75-95% eliminated in the urine as metabolites. Some is also is distributed in breast milk.
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
May cause hypotension or cardiac suppression May cause nausea and vomiting Possible liver toxicant
No information available
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Not listed (Not listed)
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lidocaine
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xilocaina
lidocaina
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Record last updated:
16/03/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242