Estriol
Last updated: 14/04/2021
(Also known as: trihydroxyestrin; estratriol; trihydroxyoestrin)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A hormonal drug used to treat urinary incontinence in bitches
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Dogs
Isomeric
C₁₈H₂₄O₃
CC12CCC3C(C1CC(C2O)O)CCC4=C3C=CC(=C4)O
C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@H]([C@@H]2O)O)CCC4=C3C=CC(=C4)O
PROQIPRRNZUXQM-ZXXIGWHRSA-N
InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
estriol
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Hormone therapy, Medicinal drug
Estrogen
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Natural
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[Estrogen receptor, agonist], [Estrogen receptor beta, agonist]
50-27-1
200-022-2
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QG03CA04
Genito urinary system & sex hormones: Sex hormones and modulators of the genital system
No
No data
288.38
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(8R,9S,13S,14S,16R,17R)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,16,17-triol
(16α,17β)-estra-1,3,5(10)-triene-3,16,17-triol
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White crystalline solid
Incurin 1mg Tablets
Intervet International BV
EU Centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually provided in tablet form for oral administration
441
Moderate
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282.0
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2.82 X 1002
Calculated
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2.45
Low
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1.27
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2.62 X 10-05
Low volatility
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Max @ 280nm
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Soil adsorption and mobility
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Low risk
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Based on LogP < 3
Low risk
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None
Terrestrial ecotoxicology
> 2000
Rat
Low
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HUMAN HEALTH AND PROTECTION
Intermediate (class II)
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> 2000
Rat
Low
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Urinary
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
✓Yes, known to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E2 E = Unspecified genotoxicity type (miscellaneous data source) 2 = Mixed/ambiguous results
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
?Possibly, status not identified
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
May increase the risk of blood clotting May cause hypertension, thromboembolic disorders and fluid retention
Reactive with oxidising agents and light sensitive
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None - not a ppp
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estriol
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estriolo
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Record last updated:
14/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242