Cefazolin
Last updated: 30/08/2023
(Also known as: cefazoline; cephazolin; HSDB 3213; cefazolin acid)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A drug used to treat Gram-positive and some Gram-negative bacterial infections of the skin and those involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract.
-
-
Horses
-
C₁₄H₁₄N₈O₄S₃
CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)O
CC1=NN=C(S1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)O
MLYYVTUWGNIJIB-BXKDBHETSA-N
InChI=1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/t9-,12-/m1/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
Cefazolin sodium pentahydrate
Variant
Antibiotic, Antibacterial, Medicinal drug
Cephalosporin
-
-
Semi-synthetic
Interferes with the later stages of bacterial cell wall synthesis
[Penicillin-binding protein 1A, antagonist], [Penicillin-binding protein 1B, antagonist], [Penicillin-binding protein 1C, antagonist], [Penicillin-binding protein 2, antagonist], [Peptidoglycan synthetase ftsI, antagonist], [Serum paraoxonase/arylesterase 1, antagonist]
25953-19-9
247-362-8
-
-
33255
QJ51DA04
Antiinfectants for systemic use: Antibacterials for intramammary use
No
Allowed susbstance (Table 1: Bovine, Ovine, Caprine)
454.51
-
(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
-
-
-
White to yellowish-white, odorless crystalline powder
None identified
None identified
No UK authorisation for use with animals
Not applicable
Usually administrated by either intramuscular or intravenous infusion
210
at 25 °C
Moderate
-
-
-
198
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
-
-
-
-
-
-
-
-
-
-
2.63 X 10-01
Calculated
-
-0.58
Low
-
-
-
-
-
-
-
-
-
3.6
-
-
2.0 X 10-13
Low volatility
-
-
-
Max = 272nm with a possible shoulder above 290nm)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Soil adsorption and mobility
-
Very mobile
12
Estimated
-
-
-
-
-
-
-
-
-
-
Low risk
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Based on LogP < 3
Low risk
-
-
None
Terrestrial ecotoxicology
> 11000
Mouse
Low
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
> 1000
R4 R = Peer reviewed scientific publications 4 = Verified data
Selenastrum capricornutum as sodium salt
Low
> 1000
R4 R = Peer reviewed scientific publications 4 = Verified data
Selenastrum capricornutum as sodium salt
Low
-
-
-
-
-
-
HUMAN HEALTH AND PROTECTION
High (class III)
-
-
> 11000
Mouse
Low
-
-
-
-
-
-
Intramuscular LD₅₀ > 4000 mg kg⁻¹
Mouse
-
Intravenous LD₅₀ > 3000 mg kg⁻¹
Mouse
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Excreted virtually unchanged in the urine
-
Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
XNo, known not to cause a problem
?Possibly, status not identified
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
XNo, known not to cause a problem
?Possibly, status not identified
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May cause gastrointestinal problems May cause hypoprothrombinemia or hypersensitivity Possible liver toxicant
No information available
-
Not listed (Not listed)
-
-
-
cefazolin
cefazoline
-
-
-
cefazolina
-
-
-
-
-
-
Record last updated:
30/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242