Thiamphenicol
Last updated: 26/04/2021
(Also known as: thiophenicol; dextrosulphenidol; Win 5063-2; thiocymetin)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A broad spectrum antimicrobial and immunosuppressive substance intended for the treatment of infectious diseases in cattle, pigs and poultry
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Cattle, Pigs, Poultry
Isomeric
C₁₂H₁₅Cl₂NO₅S
CS(=O)(=O)C1=CC=C(C=C1)C(C(CO)NC(=O)C(Cl)Cl)O
CS(=O)(=O)C1=CC=C(C=C1)[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O
OTVAEFIXJLOWRX-NXEZZACHSA-N
InChI=1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
thiamphenicol
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Antibiotic, Antimicrobial
Unclassified substance
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Synthetic
Peptidyl transferase - inhibits protein synthesis in bacteria.
[Dr hemagglutinin structural subunit, inhibitor]
15318-45-3
239-355-3
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QJ51BA02
Antiinfectants for systemic use: Antibacterials for intramammary use
No
Allowed substance (Table 1: All food producing species)
356.22
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2,2-dichloro-N-{(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl}acetamide
2-dichloroacetamido-1-(4-methylsulfonylphenyl)-1,3-propanediol
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White crystalline powder
None identified
None identified
No UK authorisation for use with animals
Not applicable
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5.00
Low
50
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Methanol
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20
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Ethanol
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1.0
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Ethyl acetate
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1.0
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Chloroform
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164
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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4.68 X 10-01
Calculated
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-0.33
Low
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Soil adsorption and mobility
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Low risk
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Based on LogP < 3
Low risk
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None
Terrestrial ecotoxicology
> 3000
Rat
Low
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8.86
R4 R = Peer reviewed scientific publications 4 = Verified data
Selenastrum capricornutum
Moderate
4.06
R4 R = Peer reviewed scientific publications 4 = Verified data
Selenastrum capricornutum
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 3000
Rat
Low
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Intravenous LD₅₀ = 339 mg kg⁻¹
Rat
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Intraperitoneal LD₅₀ > 5000 mg kg⁻¹
Rat
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Thiamphenicol is excreted in the urine largely in unchanged
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
Possible testes, bone marrow, liver & kidney toxicant Harmful if swallowed May cause gastrointestinal problems
No information available
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None - not a ppp
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thiamphenicol
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tiamfenicol
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Record last updated:
26/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242