Bacitracin |
![]() Last updated: 07/04/2021 |
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(Not known by any other names) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
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An antibiotic directed primarily against Gram-positive infections and used as a growth promotor | |
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1945, isolated | |
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Meat poultry, Pigs, Sheep, Cattle, Rabbits |
Chemical structure |
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Isomeric | |
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C₆₆H₁₀₃N₁₇O₁₆S | |
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CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCCCCC(C(=O)NC(C(=O)N1)CCCN)NC(=O)C(C(C)CC)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C2CSC(=N2)C(C(C)CC)N)CC(=O)N)CC(=O)O)CC3=CN=CN3)CC4=CC=CC=C4 | |
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CC[C@H](C)[C@@H]1C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)NCCCC[C@@H](C(=O)N[C@@H](C(=O)N1)CCCN)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSC(=N2)[C@H]([C@@H](C)CC)N)CC(=O)N)CC(=O)O)CC3=CN=CN3)CC4=CC=CC=C4 | |
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CLKOFPXJLQSYAH-KWOGWQNJSA-N | |
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InChI=1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35-,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48-,52-,53-,54+/m0/s1 | |
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Yes |
General status |
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Antibiotic, Antibacterial, Antimicrobial, Feed additive, Growth promotor | |
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Polypeptide | |
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Natural | |
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Inhibits the biosynthesis of bacterium cell wall | |
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[C55-isoprenyl pyrophosphate, antagonist], [Insulin-degrading enzyme, antagonist]; [Alpha-2-macroglobulin, antagonist] | |
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1405-87-4 | |
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215-786-2 | |
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QA07AA93 | |
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Alimentary tract & metabolism: Intestinal anti-infective | |
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No | |
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Allowed substance (Table 1: Bovine, Rabbit) | |
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1422.69 | |
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(4R)-4-[(2S)-2-({2-[(1S)-1-amino-2-methylbutyl]- 4,5-dihydro-1,3-thiazol-5-yl}formamido)-4-methylpentanamido]-4-{[(1S)- 1-{[(3S,6R,9S,12R,15S,18R,21S)- 18-(3-aminopropyl)-12-benzyl-15-(butan-2-yl)-3-(carbamoylmethyl)- 6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-2,5,8,11,14,17,20- heptaoxo-1,4,7,10,13,16,19-heptaazacyclopentacosan-21-yl]carbamoyl}- 2-methylbutyl]carbamoyl}butanoic acid | |
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Banned in EU as growth promotor; Not approved as feed additive in EU | |
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White to yellow coloured, hygroscopic solid | |
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Formulations |
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None identified | None identified | No UK authorisation for use with animals | Not applicable | ||||||
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Is not effective orally but useful in topical formulations or via intramuscular administration |
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223 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Decomposes before boiling | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.58 X 10-01 | Calculated | - | |||||||
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-0.8 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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17 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
Non-persistent | |||||||
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General literature DT₅₀ range 12-22.5 days | ||||||||||
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22.5 | R4 R = Peer reviewed scientific publications Soil & chicken manure at 20 °C4 = Verified data |
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Soil adsorption and mobility |
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Fate indices |
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Low risk | Q3 Q = Miscellaneous data from online sources Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||||||||||||||||||||
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Known soil and groundwater metabolites |
None
Other known metabolites |
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desamidobasitracin | - | Chickens; Pigs | - | - |
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Terrestrial ecotoxicology |
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> 3751 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse4 = Verified data |
Low | ||||||||
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> 316 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Colinus virginianus3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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30.5 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
Moderate | ||||||||
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5 | R3 R = Peer reviewed scientific publications Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 3751 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse4 = Verified data |
Low | ||||||||
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Intraperitoneal LD₅₀ = 190 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Subcutaneous LD₅₀ = 1300 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Poisonous by intraperitoneal and intravenous routes | ||||||||||
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Some metabolism, excreted in the urine within 24 hr | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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May cause contact dermititis or skin sensitisation May cause gastrointestinal problems May cause delayed hypersensitivity |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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bacitracin | ||
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bacitracine | ||
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bacitracina | ||
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Record last updated: | 07/04/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |