Carbadox
Last updated: 08/04/2021
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A drug used to treat Gram-negative bacterial infections including swine dysentary
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Pigs, Cattle
Isomeric
C₁₁H₁₀N₄O₄
COC(=O)N=NC=C1C=[N+](C2=CC=CC=C2N1O)[O-]
COC(=O)N=N/C=C/1\C=[N+](C2=CC=CC=C2N1O)[O-]
BPMVRAQIQQEBLN-OBPBNMOMSA-N
InChI=1S/C11H10N4O4/c1-19-11(16)13-12-6-8-7-14(17)9-4-2-3-5-10(9)15(8)18/h2-7H,1H3,(H,13,16)/b12-6+
Yes
Antibacterial, Antimicrobial, Medicinal drug, Growth promotor, Feed additive
Quinoxaline
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Synthetic
Unknown
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6804-07-5
229-879-0
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613-050-00-9
QJ01MQ
Antiinfectants for systemic use: Antibacterials for system use
No
No data
262.22
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methyl (2E)-2-[(1,4-dioxidoquinoxalin-2-yl) methylene]hydrazinecarboxylate
2-(methoxycarbonylhydrazonomethyl)quinoxaline 1,4-dioxide
Banned in many countries as a growth promotor; Not approved as feed additive in EU; Evidence of use in third world countries;
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Yellow crystalline solid
None identified
None identified
No UK authorisation for use with animals
Not applicable
As a growth promotor it was formulated as a premix or feed additive
15000
High
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239
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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4.27 X 10-02
Calculated
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-1.37
Low
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1.44
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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8.6 X 10-05
Low volatility
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Soil adsorption and mobility
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Low risk
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Based on LogP < 3
Low risk
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Known soil and groundwater metabolites
None
desoxycarbadox
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Swine (plasma)
0.190
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carbadoxaldehyde
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Swine (plasma)
0.130
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quinoxaline-2-carboxylic acid
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Swine (plasma)
0.190
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hydrazine
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Swine (plasma, urine)
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Terrestrial ecotoxicology
> 50
Rat
High
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 50
Rat
High
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Rapidly absorbed through the skin
Metabolises and eliminated in the urine
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Carcinogen
Endocrine disruptor
?Possibly, status not identified
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E1 E = Unspecified genotoxicity type (miscellaneous data source) 1 = Positive
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
?Possibly, status not identified
 
Possile adrenal & liver toxicant May cause photosensitisation
Flammable
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None - not a ppp
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carbadox
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Record last updated:
08/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242