Cilostazol (Ref: OPC-13013)
Last updated: 08/04/2021
(Also known as: cilostazolum; cilostazole)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A novel drug being explored for veterinary applications
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Dogs
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C₂₀H₂₇N₅O₂
C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4
No data
RRGUKTPIGVIEKM-UHFFFAOYSA-N
InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
cilostazol
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Antiplatelet agent, Antithrombotic agent, Medicinal drug
Quinolone
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Synthetic
A selective inhibitor of 3-type phosphodiesterase (PDE3) with therapeutic focus on increasing cAMP
[cGMP-inhibited 3',5'-cyclic phosphodiesterase A, antagonist]
73963-72-1
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QB01AC23
Blood and blood forming organs: Antithrombotic agents
No
No data
369.46
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6-(4-(1-cyclohexyl-1H-1,2,3,4-tetrazol-5-yl)butoxy)-1,2,3,4-tetrahydroquinolin-2-one
6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-,4-dihydro-2(1H)-quinolinone
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White crystalline powder
None identified
None identified
No UK authorisation for use with animals
Not applicable
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160
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2.00 X 1002
Calculated
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2.3
Low
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Soil adsorption and mobility
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Low risk
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Based on LogP < 3
Low risk
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Known soil and groundwater metabolites
None
3,4-dihydro-6-[4-(1-(trans-4-hydroxycyclohexyl-1H-tetrazol-5-yl)butoxy]-2(1H-quinolinone) (Ref: OPC-13213) Note: Pharmacologically active
HC; 4'-trans-hydroxycilostazol
Rat (Urine)
~0.3% administered dose
Cytochrome P450 3A
(6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)- butoxy]-2(1H-quinolinone) (Ref: OPC-13015) Note: Pharmacologically active
DHC; 3,4-dehydrocilostazol
Rat (Urine)
~0.02% administered dose
Cytochrome P450 3A
[6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-4-hydroxy-2(1H)-quinolinone] (Ref: OPC-13326) Note: Pharmacologically active
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Rat (Liver)
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Cytochrome P450 3A4 Cytochrome P450 1B1 Cytochrome P450 35A
3,4-dihydro-6-[4-[1-(cis-4-hydroxycyclohexyl)-1H-tetrazol-5-yl)butoxy]-2(1H)-quinolinone)]. (Ref: OPC-13217) Note: Pharmacologically active
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Rat (Liver)
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Cytochrome P450 2C8 Cytochrome P450 2C19 Cytochrome P450 3A4 Cytochrome P450 3A5
Ref: OPC-13366
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Ref: OPC-13388
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Ref: OPC-13269
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Terrestrial ecotoxicology
> 5000
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Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 5000
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Low
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Intraperitoneal LD₅₀ > 2000 mg kg⁻¹
Rat
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Intramuscular LD₅₀ > 1000 mg kg⁻¹
Rat
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Fully metabolised which are largely excreted in the urine with <20% being eliminated in the faeces
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May cause headaches and gastrointestinal problems May cause hypertension
{No information available
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Not listed (Not listed)
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cilostazol
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Record last updated:
08/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242