Atipamezole hydrochloride (Ref: NSC 71310)
Last updated: 30/08/2023
(Also known as: atipamezole HCl)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A veterinary drug used to reverse the sedative and analgesic effects of the drugs dexmedetomidine and medetomidine.
Current
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Dogs; Cats; Elephants; Bears; Ferrets; Apes
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C₁₄H₁₇ClN₂
CCC1(CC2=CC=CC=C2C1)C3=CN=CN3.Cl
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PCCVCJAQMHDWJY-UHFFFAOYSA-N
InChI=1S/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
atipamezole hydrochloride
Parent
Sedative antidote
Unclassified substance
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Synthetic
Alpha2 adrenergic receptor antagonist which selectively and competitively inhibits alpha2-adrenergic receptors
[Alpha-2 adrenergic receptor, Antagonist]
13649426
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QV03AB90
Antidotes: Atipramezole
No
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248.75
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5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole; hydrochloride
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Crystalline solid
Antisedan
Pfizer
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Sedastop
Animal Care Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Antipam
Jurox, Australia
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Revertor 5
CP Pharma
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 50
P3 P = Other non-EU, UK or US Governments and Regulators 3 = Unverified data of known source
Rat
High
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HUMAN HEALTH AND PROTECTION
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> 50
P3 P = Other non-EU, UK or US Governments and Regulators 3 = Unverified data of known source
Rat
High
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Subcutaneous TDLo = 0.1 mg kg⁻¹
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Rat
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Metabolised in the liver and rapidly (2-3 hrs) eliminated in urine.
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
XNo, known not to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
May cause cardiovascular effects Possible CNS toxicant
Not compatible with strong oxidising agents Will release toxic gases if heated to decomposition
Health: H301, H311, H331
Not listed (Not listed)
None allocated
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atipamezole hydrochloride
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Record last updated:
30/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242