Pantoprazole
Last updated: 23/04/2021
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A human and veterinary drug used to treat erosive esophagitis and other conditions involving excess stomach acid
Current
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Dogs; Cats; Llamas & Alpacas
The technical material is a 1 : 1 racemate mixture
C₁₆H₁₅F₂N₃O₄S
COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC
No data
IQPSEEYGBUAQFF-UHFFFAOYSA-N
InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)
Yes
Medicinal drug: Proton pump inhibitor
Unclassified substance
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Synthetic
Inhibits gastic acid secretion by inhibiting the K+/H+ pump
[Potassium-transporting ATPase alpha chain 1, Inhibitor]
102625-70-7
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4679
QA02BD11
Alimentary tract and metabolism Drugs for acid related disorders
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383.37
6-(difluoromethoxy)-2-((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H-benzimidazole
6-(difluoromethoxy)-2-((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H-benzimidazole
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Off-white coloured powdery solid
Protonix
Pfizer
No UK National authorisation
Not applicable
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48
at 25 °C
Low
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Decomposes before melting
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Decomposes before boliing
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139
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1.58 X 1002
Calculated
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2.2
estimated
Low
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3.92
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pKa(2)=8.19
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
747
P4 P = Other governments and regulators 4 = Verified data
Rat
Moderate
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> 95
P4 P = Other governments and regulators 4 = Verified data
Pimephales promelas
Moderate
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> 95
P4 P = Other governments and regulators 4 = Verified data
Daphnia magna
Moderate
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48
P4 P = Other governments and regulators 4 = Verified data
Pseudokirchneriella subcapitata
Low
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HUMAN HEALTH AND PROTECTION
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747
P4 P = Other governments and regulators 4 = Verified data
Rat
Moderate
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Intravenous LD₅₀ = 256 mg kg⁻¹
P4 P = Other governments and regulators 4 = Verified data
rat
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Occupational exposure to pantoprazole may occur through inhalation and dermal contact
Heptic metabolism, renal elimination within a few hours
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Carcinogen
Endocrine disruptor
?Possibly, status not identified
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E2 E = Unspecified genotoxicity type (miscellaneous data source) 2 = Mixed/ambiguous results
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
May cause headache, diarrhoea, nausea, abdominal pain, vomiting, flatulence, dizziness, and joint pain May cause hypergastrinemia
No information available
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NL (Not listed)
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pantoprazole
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Record last updated:
23/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242