Ephedrine
Last updated: 24/06/2022
(Also known as: (-)-(1R,2S)-ephedrine; L-(-)-ephedrine )
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A veterinary and human drug used to contrict blood vessels and widen bronchial passages to relieve breathing and/or urinary difficulties
Current
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Dogs; Cats
Ephedrine is a chiral molecule.
C₁₀H₁₅NO
CC(C(C1=CC=CC=C1)O)NC
C[C@@H]([C@@H](C1=CC=CC=C1)O)NC
KWGRBVOPPLSCSI-WPRPVWTQSA-N
InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
ephedrine
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ephidrine hydrochloride
Variant
Medicinal drug: Nervous system stimulant, Bronchodilator agent
Sympathomimetic amine
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-
Synthetic
Indirect stimulation of the adrenergic receptor system by increasing the activity of norepinephrine at the postsynaptic a- and ß-receptors.
[Sodium-dependent noradrenaline transporter, Inverse agonist], [Alpha-1A adrenergic receptor, Unknown activity], [Synaptic vesicular amine transporter, Inhibitor]
299-42-3
321-98-2/4607-45-8/90-81-3
202-017-0
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9294
QG04BX90
Urologicals: Other urologicals
No
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165.23
(1R,2S)-2-(methylamino)-1-phenyl-1-propanol
(1R,2S)-2-(methylamino)-1-phenyl-1-propanol
(-)-a-(1-methylaminoethyl)benzyl alcohol
Ephedrine may interact with other sympathomimetics.
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Crystalline solid
Enurace 10
Ecuphar NV
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Enurace 50
Ecuphar NV
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
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63600
High
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-
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34
-
255
-
-
-
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1.35 X 1001
Calculated
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1.13
Low
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-
-
-
-
-
-
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10.25
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-
-
-
-
-
-
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-
-
-
-
-
-
-
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
600
Rat
Moderate
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562
Unknown species
Moderate
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HUMAN HEALTH AND PROTECTION
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600
Rat
Moderate
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Subcutaneous LD₅₀ = 300 mg kg⁻¹
Rat
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Intravenous LDLo = 150 mg kg⁻¹
Rat
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Renally eliminated mostly as unchanged drug
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
No data found
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
May invoke weight loss & nausea Possible CNS toxicant May cause flushing, sweating & acne vulgaris
No information available
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Not listed (Not listed)
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ephedrine
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Record last updated:
24/06/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242