Amantadine
Last updated: 06/04/2021
(Also known as: 1-aminoadamantane)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A veterinary drug used as an antiviral aganet and/or as pain relief caused by conditions such as arthritis and cancer mostly in dogs
Current
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Dogs
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C₁₀H₁₇N
C1C2CC3CC1CC(C2)(C3)N
No data
DKNWSYNQZKUICI-UHFFFAOYSA-N
InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
amantadine
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Medicinal drug: Antiviral agent, Pain relief
Unclassified substance
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Synthetic
Inhibits viral replication by interfering with an integral membrane protein
[Matrix protein 2, Inhibitor], [Glutamate receptor ionotropic, NMDA 3A, Antagonist], [D(2) dopamine receptor, Agonist], [Aromatic-L-amino-acid decarboxylase, Inducer]
768-94-5
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QN04BB01
Nervous system: Adamantane derivatives
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151.25
adamantan-1-amine
adamantan-1-amine
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Colourless crystalline substance
Symmetrel
Endo Pharmaceuticals
No UK authorisation
Not applicable
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6290
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160
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2.75 X 1002
Calculated
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2.44
Low
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10.45
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
800
E4 E = Manufacturers safety data sheets 4 = Verified data
Rat as hydrochloride salt
Moderate
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> 22.6
Pimephales promelas
Moderate
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> 17.4
Daphnia magna
Moderate
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HUMAN HEALTH AND PROTECTION
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800
E4 E = Manufacturers safety data sheets 4 = Verified data
Rat as hydrochloride salt
Moderate
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Rapidly and almost completely absorbed from gastrointestinal tract. Unmetabolised renal elimination (90%)
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
May cause nervousness, irritability, or insomnia, and possibly seizures May cause nausea, constipation or diarrhoea, dry mouth, and loss of appetite
No information available
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Not listed (Not listed)
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amantadine
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Record last updated:
06/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242