Amlodipine
Last updated: 30/08/2023
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A veterinary and human drug used to slow the heart beat, relax blood vessel walls and so treat high blood pressure
Current
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Cats
Amlodipine technical material is a 1 : 1 racemate mixture
C₂₀H₂₅ClN₂O₅
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
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HTIQEAQVCYTUBX-UHFFFAOYSA-N
InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
Yes
Medicinal drug: Vasodilator agent; Heart
Dihydropyridine
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Synthetic
Amlodipine slows the rate at which calcium moves into the heart and blood vessel walls.Calcium channel blocker.
[Voltage-dependent L-type calcium channel subunit alpha-1C, Inhibitor], [Voltage-dependent calcium channel subunit alpha-2/delta-1, Inhibitor], [Voltage-dependent L-type calcium channel subunit beta-2 , Inhibitor], [Voltage-dependent L-type calcium channel subunit alpha-1D, Inhibitor]
88150-42-9
618-119-7
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2162
QC10BX11
Lipid modifying agent: HMG CoA reductase inhibitors, other combinations
No
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408.88
3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylater
3-ethyl 5-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
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White powdery solid
AModip 1.25mg
Ceva Animal health
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Vivelin 1.25mg
Orion Corp
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
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75.3
at 25 °C
Moderate
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1.00 X 1003
Calculated
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3.0
Moderate
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8.79
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
37
Mouse as besylate variant
High
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HUMAN HEALTH AND PROTECTION
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37
Mouse as besylate variant
High
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Heptic metabolism. Renal excretion accounts for approx. 60% administered. The remainder is eliminated in bile and faeces.
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause swelling of ankles or feet May cause difficult or laboured breathing Possible liver & heart toxicant
Will release toxic gases if heated to decomposition Slightly flammable. May combust at high temperatures
Health: H301, H318, H373 Environment: H400, H410
Not listed (Not listed)
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amlodipine
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amlodipino
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Record last updated:
30/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242