Apomorphine
Last updated: 07/04/2021
(Also known as: apomorphin; R-(-)-apomorphine; apomorfin)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A veterinary substance used to induce vomiting in animals that have, or are suspected to have, ingested substances that may be poisonous
Current
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Dogs; Cats
Isomeric
C₁₇H₁₇NO₂
CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O
CN1CCC2=CC=CC3=C2[C@H]1CC4=C3C(=C(C=C4)O)O
VMWNQDUVQKEIOC-CYBMUJFWSA-N
InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
Yes
Medicinal drug: Emesis inducing agent
Unclassified substance
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Synthetic
Non-selective dopamine agonist which activates both D1-like and D2-like receptors
[D(3) dopamine receptor, Agonist], [D(4) dopamine receptor, Agonist], [D(2) dopamine receptor, Agonist], [Alpha-2C adrenergic receptor, Agonist]
41372-20-7
200-360-0
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No
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267.322
(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
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Colourless liquid with green stain
Apometic 10
Forum Products limited
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
EMEDOG 1
Laboratoire TVM
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
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16600
High
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Decomposes before melting
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Decomposes before boiling
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195
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2.00 X 1002
Calculated
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2.30
Low
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8.92
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pK(b) = 7.0
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
300
Mouse
Moderate
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HUMAN HEALTH AND PROTECTION
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300
Mouse
Moderate
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Intraperitoneal LD₅₀ = 160 mg kg⁻¹
Mouse
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Intravenous LD₅₀ = 56 mg kg⁻¹
Mouse
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
No data found
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
May cause hypotension, drowsiness and/or sedation, dyskinesia and protracted vomiting CNS toxicant
When heated to decomposition it emits highly toxic fumes of nitrogen oxides
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Not listed (Not listed)
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apomorphine
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Record last updated:
07/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242