Cefpodoxime
Last updated: 14/09/2023
(Also known as: Simplcef)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Cefpodoxime is an oral, third-generation cephalosporin antibiotic active against most Gram-positive and Gram-negative organisms.
Current
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Dogs; Cats
Isomeric
C₁₅H₁₇N₅O₆S₂
COCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)O
COCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OC)/C3=CSC(=N3)N)SC1)C(=O)O
WYUSVOMTXWRGEK-HBWVYFAYSA-N
InChI=1S/C15H17N5O6S2/c1-25-3-6-4-27-13-9(12(22)20(13)10(6)14(23)24)18-11(21)8(19-26-2)7-5-28-15(16)17-7/h5,9,13H,3-4H2,1-2H3,(H2,16,17)(H,18,21)(H,23,24)/b19-8-/t9-,13-/m1/s1
Yes
Medicinal prodrug: antibiotic
Cephalosporin
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Synthetic
Acts by interfering with the formation of the bacteria's cell wall so that the wall ruptures, resulting in bacterial death
[Peptidoglycan synthase FtsI, Inhibitor]
82619-04-3
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6335986
QJ01DD13
Other Beta-Lactam antibacterials: Third-generation cephalosporins
No
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427.46
(6R,7R)-7-(((2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl)amino)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
(6R,7R)-7-(((2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl)amino)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
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Orange to red coloured solid
Proxetil
Pfizer
No UK National authorisation
Not applicable
Vantil
Pfizer
No UK National authorisation
Not applicable
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0.4
Low
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
cefpodoxime Note: Active metabolite
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Humans; Animals
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Terrestrial ecotoxicology
> 8000
Mouse
Low
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HUMAN HEALTH AND PROTECTION
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> 8000
Mouse
Low
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Intraperitoneal LD₅₀ = 2535 mg kg⁻¹
P3 P = Other non-EU, UK or US Governments and Regulators 3 = Unverified data of known source
Mouse
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Subcutaneous LD₅₀ > 10000 mg kg⁻¹
P3 P = Other non-EU, UK or US Governments and Regulators 3 = Unverified data of known source
Mouse
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Absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. Excreted rapidly in the urine (approx. 12 hrs)
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
?Possibly, status not identified
✓Yes, known to cause a problem
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May cause mild gastro-intestinal problems including diarrhoea, nausia and vomiting May cause sensitisation via contact or inhalation
No information available
Health: H317, H334
Not listed (Not listed)
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cefpodoxime
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cefpodoxima
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Record last updated:
14/09/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242