Diphenhydramine
Last updated: 24/06/2022
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
Diphenhydramine is used in veterinary practice to treat allergies and atopy primarily in dogs but also in some other species.
Current
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Dogs; Cats; Horses
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C₁₇H₂₁NO
CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2
No data
ZZVUWRFHKOJYTH-UHFFFAOYSA-N
InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
Diphenhydramine hydrochloride
Variant
Medicinal drug: histamine blocker
Diphenylmethane
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Synthetic
Diphenhydramine competes with free histamine for binding at HA-receptor sites.
[Histamine H1 receptor, Antagonist], [Muscarinic cholinergic receptors (Ki = 100 to 260 nM for M1 through M5), Antagonist]
58-73-1
1720-32-7/184163-39-1
200-396-7
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QR06AA02
Antihistamines for systemic use: Aminoalkyl ethers
No
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255.36
2-(diphenylmethoxy)-N,N-dimethylethanamine
2-(diphenylmethoxy)-N,N-dimethylethanamine
2-((diphenylmethyl)oxy)-N,N-dimethylethanamine
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Powdery solid
3060
High
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161
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150
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1.86 X 1003
Calculated
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3.27
High
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8.89
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
160
Mouse
Moderate
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-
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> 0.525
Ceriodaphnia dubia
Moderate
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-
-
-
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-
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-
-
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HUMAN HEALTH AND PROTECTION
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160
Mouse
Moderate
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Intraperitoneal LD₅₀ = 56.0 mg kg⁻¹
Mouse
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Intravenous LD₅₀ = 42.0 mg kg⁻¹
Mouse
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Excreted mostly unchanged in urine.
Ceriodaphnia dubia
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Carcinogen
Endocrine disruptor
?Possibly, status not identified
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E2 E = Unspecified genotoxicity type (miscellaneous data source) 2 = Mixed/ambiguous results
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
?Possibly, status not identified
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
Possible liver & kidney toxicant Sedative CNS depressant High doses may cause myocardial infarction (heart attack)
Will produce toxic gases when heated to decomposition
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NL (Not listed)
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diphenhydramine
diphenhydramine
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difenhidramina
difenhidramina
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Record last updated:
24/06/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242