Enalapril maleate (Ref: MK 421)
Last updated: 14/04/2021
(Also known as: Renitek)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A veterinary prodrug used to treat hypertension, symptomatic heart failure, and asymptomatic left ventricular dysfunction
Current
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Cats; Dogs
Isomeric
C₂₄H₃₂N₂O₉
CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CCCC2C(=O)O.C(=CC(=O)O)C(=O)O
CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)O.C(=C\C(=O)O)\C(=O)O
OYFJQPXVCSSHAI-QFPUQLAESA-N
InChI=1S/C20H28N2O5.C4H4O4/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25;5-3(6)1-2-4(7)8/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,16-,17-;/m0./s1
Yes
Medicinal drug: hypertension agent
Peptide
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Synthetic
Undergoes biotransformation to the active enalaprilat. An angiotensin-converting-enzyme (ACE) inhibitor; Blocks the angiotensin-converting enzyme.
[Angiotensin-converting enzyme, Inhibitor]
76095-16-4
75847-73-3
278-375-7
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QC09AA02
Agents acting on the renin-angiotensin system: ACE inhibitors, plain; Antihypertensive drug
No
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492.52
(S)-1-(N-(1-(Ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-L-proline
(S)-1-((S)-2-(1-((S)-ethoxycarbonyl)-3-phenyl-propylamino)-propionyl)-pyrrolidine-2-carboxylic acid
1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline 1'-ethyl ester
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White to off-white crystalline powder
Enacard Tablets for Dogs 1 mg
Merial Animal Health
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Prilenal 10 mg, Tablets
Ceva Animal Health Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied in tablet form for oral administration
16400
at 25 °C
High
80.0
Ethanol
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200
Methanol
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143
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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165.3
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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416.7
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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1.17 X 1000
Calculated
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0.07
Low
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2.97
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pKa(2)=5.35
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
enalapril
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Animals inc. humans
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Terrestrial ecotoxicology
2973
Rat
Low
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> 1000
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Pimephales promelas
Low
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354
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Daphnia magna
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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2973
Rat
Low
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Subcutaneous LD₅₀ = 1418 mg kg⁻¹
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Rat
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Intravenous LD₅₀ = 849 mg kg⁻¹
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Rat
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Hepatic metabolism, renal excretion. Some evidence of some loss in maternal milk
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
May cause dizziness, low blood pressure, synope and a dry cough Possible kidney toxicant
Will produce toxic gases when heated to decomposition Reactive with oxidising agents
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NL (Not listed)
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enalapril maleate
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Record last updated:
14/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242