Gabapentin
Last updated: 14/05/2022
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A veterinary substance used to treat epilepsy and neuropathic pain
Current
1993
Cats; Dogs
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C₉H₁₇NO₂
C1CCC(CC1)(CC(=O)O)CN
No data
UGJMXCAKCUNAIE-UHFFFAOYSA-N
InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
gabapentin
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Medicinal drug: Anticonvulsant & Pain Reliever
Gamma amino-acid
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Synthetic
Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels
[Voltage-dependent calcium channel subunit alpha-2/delta-1, Inhibitor], [Voltage-dependent calcium channel subunit alpha-2/delta-2, Inhibitor], [Voltage-dependent N-type calcium channel subunit alpha-1B , Inhibitor], [Adenosine receptor A1 , Agonist], [NMDA receptor, Unknown action]
60142-96-3
262-076-3
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QN03AX12
Antiepileptics: Other antiepileptics
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171.24
1-(aminomethyl)cyclohexaneacetic acid
1-(aminomethyl)cyclohexaneacetic acid
1-(aminomethyl)cyclohexaneacetic acid
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White to off-white crystalline solid
Neurontin
Pfizer
No UK national authorisation
Not applicable
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4500
High
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162
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7.94 X 10-02
Calculated
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-1.1
Low
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3.68
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pKa(2)=10.70
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 8053
Rat
Low
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50
Danio rerio as mM
Low
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HUMAN HEALTH AND PROTECTION
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> 8053
Rat
Low
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Intravenous LD₅₀ > 1000 mg kg⁻¹
Mouse
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Renal excretion as unchanged drug
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Carcinogen
Endocrine disruptor
?Possibly, status not identified
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
May cause vomiting, drowsiness, loss of balance and/or diarrhoea May cause calcium, vitamin D, vitamin B1 & folate deficiencies
Will emit toxic gases when heated to decomposition
Health: H315, H319, H360, H335
NL (Not listed)
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gabapentin
gabapentine
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gabapentino
gabapentina
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Record last updated:
14/05/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242