Hydromorphone
Last updated: 26/05/2022
(Also known as: dihydromorphinone)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A controlled veterinary drug, which is a morphine analogue usually used as the hydrochloride salt, used mainly as a sedative, restraining agent, analgesic or preanesthetic.
Current
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Dogs; Cats
Isomeric
C₁₇H₁₉NO₃
CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(=O)CC4
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4
WVLOADHCBXTIJK-YNHQPCIGSA-N
InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
hydromorphone
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Medicinal drug: analgesic
Opoid
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Synthetic
Acts by stimulating opiate receptors in CNS
[Mu-type opioid receptor, Agonist], [Delta-type opioid receptor, Partial agonist], [Kappa-type opioid receptor, Agonist]
466-99-9
207-383-5
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QN02AA03; QN02AG04
Analgesics: Opiods
Yes: Narcotic
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285.34
(4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro(3,2-e)isoquinoline-7-one
(4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro(3,2-e)isoquinoline-7-one
4,5-epoxy-3-hydroxy-17-methylmorphinan-6-one
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White to slightly yellow crystalline solid
Dilaudid
Purdue Pharma, Canada
No UK national authorisation
Not applicable
Exalgo
Mallinckrodt
No UK national authorisation
Not applicable
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1931
at 25 °C
High
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266
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100
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1.29 X 1000
Calculated
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0.11
Low
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Soil adsorption and mobility
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Mobile
30
Estimated
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3.0
Low potential
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None
Terrestrial ecotoxicology
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HUMAN HEALTH AND PROTECTION
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Subcutaneous LD₅₀ = 84.0 mg kg⁻¹
Mouse
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Intravenous LD₅₀ = 104 mg kg⁻¹
Mouse
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Metabolized in the liver as glucuronidated conjugate (major metabolite) and 6-hydroxy (minor metabolite) and excreted in the urine
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
XNo, known not to cause a problem
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
✓Yes, known to cause a problem
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
CNS toxicant - may cause respiratory depression, sedation and bradycardia Skin & respiratory sensitiser
When heated to decomposition it emits toxic fumes of nitroxides Closed containers may explode from the heat of fire
Helth: H317, H334; H336, H361
NL (Not listed)
Not regulated
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hydromorphone
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hydromorfona
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Record last updated:
26/05/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242