Levetiracetam
Last updated: 21/04/2021
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A relatively new anticonvulsant drug used in animals and humans to help prevent epileptic seizureseizures
Current
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Dogs; Cats
Isomeric
C₈H₁₄N₂O₂
CCC(C(=O)N)N1CCCC1=O
CC[C@@H](C(=O)N)N1CCCC1=O
HPHUVLMMVZITSG-LURJTMIESA-N
InChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m1/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
levetiracetam
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Medicinal drug: anti-epileptic
Fatty amide
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Synthetic
Levetiracetam binds to the synaptic vesicle protein SV2A, which is thought to be involved in the regulation of vesicle exocytosis.
[Synaptic vesicle glycoprotein 2A, Agonist], [Voltage-dependent N-type calcium channel subunit alpha-1B, Inhibitor]
102767-28-2
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QN03AX14
Antiepileptics
No
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170.21
(2R)-2-(2-oxopyrrolidin-1-yl)butanamide
(S)-2-(2-Oxopyrrolidin-1-yl)butanamide
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Crystalline solid
Keppra
levetiracetam
No UK national authorisation
Not applicable
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298000
High
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2.29 X 10-01
Calculated
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-0.64
Low
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
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HUMAN HEALTH AND PROTECTION
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Intravenous LD₅₀ = 1038 mg kg⁻¹
Rat
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66% of the dose is renally excreted unchanged.
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Possible liver toxicant CNS toxicant - may cause somnolence, decreased energy, headache, dizziness, and coordination difficulties
Will emit toxic fumes when heated to decomposition
Health: H302, H319
Not listed (Not listed)
Not regulated
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levetiracetam
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Record last updated:
21/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242