The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Human health Moderate alert: Mammals acute toxicity: Moderate; Possible Carcinogen; Neurotoxicant
GENERAL INFORMATION
Description
A veterinary substance which is a noradrenergic and specific serotonergic antidepressant (NaSSA) that is used to manage anorexia and behavioral disorders in domestic pets
Acts as an antagonist at central pre-synaptic alpha(2)-receptors, inhibiting negative feedback to the presynaptic nerve and causing an increase in NE release.
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242