The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Human health Low alert
GENERAL INFORMATION
Description
A human and veterinary antimicrobial drug, usually used as the hydrochloride salt, active against both Gram-positive and Gram-negative bacteria.
Binds to and inhibits the bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV, resulting in inhibition of DNA replication and repair and cell death in sensitive bacterial species
Molecular targets
[DNA gyrase subunit A, Inhibitor], [DNA topoisomerase 4 subunit A, Inhibitor], [DNA topoisomerase 2-alpha, inhibitor]
CAS RN
354812-41-2
EC number
604-773-0
CIPAC number
-
US EPA chemical code
-
PubChem CID
-
ATCvet Code
QJ01MA14; QS01AE07
Therapeutic Class
Antibacterials for systemic use - Quinolone antibacterials; Ophthalmologicals - Antiinfectives
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242